J Korean Med Sci.  1998 Dec;13(6):665-669. 10.3346/jkms.1998.13.6.665.

Sjogren's syndrome with acute renal failure

• Kwon YJ
• Park JH
• Kim SW
• Han SY
• Pyo HJ
• Won NH

• KMID: 1038450
• DOI: http://doi.org/10.3346/jkms.1998.13.6.665

Abstract

We experienced a 65-year-old woman with Sjogren's syndrome who presented with acute renal failure, hypergammaglobulinemia with monoclonal gammopathy, and hypocomplementemia. She improved with steroid pulse therapy (methylprednisolone 0.5 g/day for 3 days). This patient had also sensorineural hearing loss, symmetric sensory polyneuropathy of legs, and interstitial lung disease. Ten months after recovery from acute renal failure, low-dose oral prednisolone (0.1 mg/kg/day) was withdrawn. On the third month of steroid withdrawal, acute renal failure recurred with hypergammaglobulinemia, hyperamylasemia, and autoimmune cholangitis-like biochemical derangements, which also responded to steroid pulse therapy (methylprednisolone 0.3 g/day for 3 days). When we would withdraw steroid in a patient with visceral involvement of Sjogren's syndrome, we should consider multiple clinical and laboratorial variables, including erythrocyte sedimentation rate, serum levels of IgG, total protein, C3/C4, CRP, amylase, lipase, and alkaline phosphatase. We report this case which exhibited various unusual manifestations with a review of literature.

MeSH Terms

Aged
Case Report
Female
Human
Kidney Failure, Acute/pathology*
Kidney Failure, Acute/complications*
Sjogren's Syndrome/pathology*
Sjogren's Syndrome/complications*