J Korean Med Sci.  1998 Aug;13(4):423-427. 10.3346/jkms.1998.13.4.423.

Sinus histiocytosis with massive lymphadenopathy. Multiple skull involvements

• Park YK
• Kim YW
• Choi WS
• Lim YJ

• KMID: 1038171
• DOI: http://doi.org/10.3346/jkms.1998.13.4.423

Abstract

Sinus histiocytosis with massive lymphadenopathy is a non-neoplastic self-limiting disease of the bone marrow stem cell origin. It is characterized by painless, bilateral cervical lymphadenopathy accompanied by fever, leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia. Extranodal involvement including bone is rare. The patient is a 45-year -old female with multiple punch out lesions on her skull. MRI findings included iso-signal intensity mass at the diploid space on T1 weighted image and on T2 weighted image, mild high signal intensity was obtained. Histologically, the lesion showed proliferation of histiocytes in the fibroblastic background with formation of reactive germinal centers and many plasma cells. The histiocytes show round nuclei and occasional nucleoli and abundant cytoplasms. In area, there is lymphocytophagocytosis. Immunohistochemically, the histiocytes were positive for S-100 protein and lysozyme.

MeSH Terms

Case Report
Female
Histiocytosis, Sinus/radiography*
Human
Lymphatic Diseases/radiography*
Middle Age
Tomography Scanners, X-Ray Computed