Korean J Intern Med.  2011 Sep;26(3):360-363. 10.3904/kjim.2011.26.3.360.

Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

• Sener O
• Kose O
• Kartal O
• Safali M

• KMID: 1022178
• DOI: http://doi.org/10.3904/kjim.2011.26.3.360

Abstract

Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.

Keyword

Methylene blue; Indigofera; Drug eruptions

MeSH Terms

Acute Generalized Exanthematous Pustulosis/*chemically induced/drug therapy/pathology
Administration, Oral
Adrenal Cortex Hormones/therapeutic use
Aged
Biopsy
Coloring Agents/administration & dosage/*adverse effects
Humans
Indoles/administration & dosage/*adverse effects
Intradermal Tests
Male
Methylene Blue/administration & dosage/*adverse effects
Skin/*drug effects/pathology
Treatment Outcome