- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
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- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
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Ko J, Yun CY, Lee JS, Kim JH, Kim IS
- KMID: 1094653
- Exp Mol Med.
- 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1... -
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- Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma
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Liu Y, Jia L, Liu ZC, Zhang H, Zhang PJ, Wan Q, Wang R
- KMID: 756208
- Exp Mol Med.
- 2009 Sep;41(9):648-655.
- doi: 10.3858/emm.2009.41.9.071
Early stage diabetic nephropathy is characterized by elevated glomerular filtration. Recent studies have identified high-glucose induced p38 MAPK (p38) over-activation in mesangial cells. Mesangial hypocontractility is the major underlying mechanism,... -
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- 14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells
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Lee EK, Lee YS, Lee H, Choi CY, Park SH
- KMID: 1058019
- Exp Mol Med.
- 2009 Jul;41(7):453-461.
- doi: 10.3858/emm.2009.41.7.050
One of the 14-3-3 protein isoforms, 14-3-3epsilon, was previously shown to be increased during skin aging. We suggest here a possible role for the 14-3-3epsilon protein in skin aging by... -
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- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
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Ha YJ, Seul HJ, Lee JR
- KMID: 1097267
- Exp Mol Med.
- 2011 Feb;43(2):101-110.
- doi: 10.3858/emm.2011.43.2.012
Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K)... -
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- Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
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Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CW
- KMID: 2155355
- Exp Mol Med.
- 2014 Apr;46(4):e90.
- doi: 10.1038/emm.2014.1
Syntenin is a PDZ domain-containing adaptor protein that has been recently shown to regulate migration and invasion in several tumors. Small cell lung cancer (SCLC) is notorious for its invasiveness... -
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- Immunohistochemical Analysis of Nuclear Factor, p38, and Cyclin D1 Proteins in Premalignant Lesions and Carcinomas of the Colorectal Mucosa
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Lee SD, Lee TJ, Park ES
- KMID: 783112
- Korean J Gastroenterol.
- 2008 Dec;52(6):359-367.
BACKGROUND/AIMS: Nuclear factor-kappa B p65 (NF-kappa B p65), nuclear factor-kappa B1 p50 (NF-kappa B p50) have been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis.... -
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- Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
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Lee SY, Kang SU, Kim KI, Kang S, Shin YS, Chang JW, Yang SS, Lee K, Lee JS, Moon E, Kim CH
- KMID: 2070214
- Yonsei Med J.
- 2014 Nov;55(6):1640-1647.
- doi: 10.3349/ymj.2014.55.6.1640
PURPOSE: To determine the effects of nonthermal plasma (NTP) induced by helium (He) alone or He plus oxygen (O2) on the generation of reactive oxygen species (ROS) and cell death... -
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- Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via p38 Mitogen-Activated Protein Kinase in a Rat Model
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Zhao B, Pan Y, Wang Z, Xu H, Song X
- KMID: 2374198
- Yonsei Med J.
- 2017 Jan;58(1):131-138.
- doi: 10.3349/ymj.2017.58.1.131
PURPOSE: To investigate the effects of hyperbaric oxygen (HBO) pretreatment on cognitive decline and neuronal damage in an Alzheimer’s disease (AD) rat model. MATERIALS AND METHODS: Rats were divided into three... -
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- Aldosterone Upregulates Connective Tissue Growth Factor Gene Expression via p38 MAPK Pathway and Mineralocorticoid Receptor in Ventricular Myocytes
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Lee YS, Kim JA, Kim KL, Jang HS, Kim JM, Lee JY, Shin IS, Lee JS, Suh W, Choi JH, Jeon ES, Byun J, Kim DK
- KMID: 1778560
- J Korean Med Sci.
- 2004 Dec;19(6):805-811.
- doi: 10.3346/jkms.2004.19.6.805
The effect of aldosterone on connective tissue growth factor (CTGF) was examined in rat embryonic ventricular myocytes. Upon aldosterone treatment, CTGF expression was significantly increased in a dose and time-dependent... -
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