- The Role of Nitric Oxide (NO) in UVB-induced Apoptosis in HaCaT Keratinocytes
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Sung KJ, Paik EM, Kim MJ, Suh CW, Suh HS, Choi JH
- KMID: 2116065
- Korean J Dermatol.
- 1999 Nov;37(11):1596-1602.
BACKGROUND: According to target cells, apoptosis-inducing agents, and NO concentration, NO concentration, NO shows both pro- and antiapoptotic effects. OBJECTS: Our study was perfermed to verify the role of NO... -
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- The Effect of Nitric Oxide on Cat Corpus Cavernosum Relaxation Under Hypoxia (In vivo Study)
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Kim YW, Kim JJ
- KMID: 2060681
- Korean J Urol.
- 1996 Nov;37(11):1209-1214.
One of the pathophysiologic change of priapism is known as hypoxic condition of corpus cavernosum. In vitro study of corpus cavernosum under hypoxia showed suppressed endothelium- dependent relaxation caused by... -
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- Effects of Adenosine Triphosphate on Relaxation of Rabbit Cavernosal Smooth Muscle
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Park HS, Kim JJ
- KMID: 2289723
- Korean J Urol.
- 1994 Aug;35(8):846-851.
Externally applied acetylcholine(Ach) in corpus cavernosum has been shown to cause endothelium dependent smooth muscle relaxation. ATP is accepted as a relaxant of smooth muscle by both a direct action... -
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- Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells
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Ryu YK, Lee JW, Moon EY
- KMID: 2380358
- Biomol Ther.
- 2015 Jan;23(1):19-25.
- doi: 10.4062/biomolther.2014.101
Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 (Tbeta4), actin sequestering protein. Here, we... -
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- The Effects of Intravesical BCG Instillation on Bladder Cancer Induced by N-butyl-N-(4-hydroxybutyl) Nitrosamine
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Song HC, Kim SW, Rim JS
- KMID: 2290227
- Korean J Urol.
- 1998 Feb;39(2):110-115.
PURPOSE: We investigate the effects of intravesical BCG therapy on the occurance of superficial bladder cancer induced by N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) in Fisher 344 rats in vivo. We also examine... -
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- Mechanism of Action of Endothelium-Dependent Relaxation Substances on Rabbit Corpus Cavernosum
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Kim JJ, Chung DY, Koh SK
- KMID: 1851751
- J Korean Androl Soc.
- 1994 Dec;12(2):109-117.
Many relaxation substances cause endothelium-dependent vasodilation of various vessels. Relaxation of penile corpus cavernosum smooth muscle is controlled by nerves and a substance known as endothelium-derived relaxation factor(EDRF). The... -
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- Possible Involvement of Ca2+ Activated K+ Channels, SK Channel, in the Quercetin-Induced Vasodilatation
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Nishida S, Satoh H
- KMID: 1982569
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):361-365.
- doi: 10.4196/kjpp.2009.13.5.361
Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2+ activated K+ (KCa)... -
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- Differential effects of nitric oxide synthase inhibitors in rats
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Lee JH, Shin CY, Kang BS, Jeong JH, Choi KB, Min YS, Kim JH, Huh IH, Sohn UD
- KMID: 1982595
- Korean J Physiol Pharmacol.
- 2000 Apr;4(2):99-104.
We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, NG-monomethyl-L-arginine (L-NMMA, 3 micrometer) or NG-nitro-L-arginine methylester (L-NAME, 30 micrometer), augmented phenylephrine (PE, 10-7 M)-induced contraction... -
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- IV Morphine Produced Spinal Antinociception Partly by Nitric Oxide
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Song HK, Park SS, Kim JT
- KMID: 2104783
- J Korean Pain Soc.
- 1998 May;11(1):1-6.
BACKGROUND: The role of nitric oxide(NO) in analgesia from opioids is controversial. On the one hand, IV morphine analgesia is enhanced by IV injection of NO synthase inhibitors. On the other hand,... -
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- Pharmacophysiological Change of Rabbit Corpus Cavernosum under Hypoxia
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Park HJ, Kim JJ, Koh SK
- KMID: 1913989
- Korean J Urol.
- 1995 Mar;36(3):247-257.
Local contributing factors in penile erection are trabecular smooth muscle, endothelium, trabecular fibroelastic components, tunica albuginea and local neuro-control. There are three neuroeffector systems in local neuro-control for penile erection.... -
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- Antinociceptive Effect of the Intrathecal Phosphodiesterase Inhibitor, Zaprinast, in a Rat Formalin Test
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Heo BY, Kim CM, Jeong ST, Kim SJ, Choi JI, Yoon MH
- KMID: 2277970
- Korean J Pain.
- 2005 Dec;18(2):99-106.
- doi: 10.3344/kjp.2005.18.2.99
BACKGROUND: Cyclic guanosine monophosphate (cGMP) and opioid receptors are involved in the modulation of nociception. Although the opioid receptors agonists are active in pain, the effect of an phospodiesterase inhibitor... -
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- Improvement in endothelial function by calcium antagonist and vitamin C in essential hypertension
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On YK, Choi JH, Chae IH, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS
- KMID: 2306119
- Korean J Med.
- 2001 Nov;61(5):518-526.
BACKGROUND: The effects of antihypertensive agents on endothelial function have not been fully evaluated in human hypertension and data on the forearm circulation of humans are controversial. The aim of... -
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- Mechanism of Impaired Endothelium-dependent Vasodilation in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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Chun KJ, Son SM, Kim IJ, Kim CD, Yoo SD, Kim YK
- KMID: 1569047
- J Korean Diabetes Assoc.
- 2002 Feb;26(1):46-56.
BACKGROUND: Impaired vascular endothelium-dependent relaxation and augmented contractile responses have been reported in several long-term animals hyperglycemia models and human diabetic patients. Since oxidative stress has been implicated as... -
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- Improvement in Endothelial Function by Angiotensin-converting Enzyme Inhibition and Vitamin C in Essential Hypertension
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On YK, Chung WY, Chae IH, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS
- KMID: 2227305
- Korean Circ J.
- 2001 Apr;31(4):411-419.
- doi: 10.4070/kcj.2001.31.4.411
BACKGROUND AND OBJECTIVES: The endothelium plays an important role in maintaining vascular tone and function. Essential hypertension may be associated with alterations in endothelial function. The effects of antihypertensive agents... -
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- Role of nitric oxide in ischemia-evoked release of norepinephrine from rat cortex slices
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Kim KW, Eun YA, Kim DC, Cho KP
- KMID: 2285185
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):673-679.
It has been generally accepted that glutamate mediates the ischemic brain damage, excitotoxicity, and induces release of neurotransmitters, including norepinephrine (NE), in ischemic milieu. In the present study, the role of nitric oxide... -
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- The Vasodilation of Protamine and the Influence of Heparin on its Actions in the Isolated Aortic Arteries of Rats
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Yoon SH, Kim YH, Kwon SB, Lee JE, Kim HJ, Choi SJ
- KMID: 2237714
- Korean J Anesthesiol.
- 1997 Oct;33(4):591-603.
- doi: 10.4097/kjae.1997.33.4.591
BACKGROUND: When used to reverse the anticoagulant effect of heparin, protamine administration after cardiovascular bypass often can lead to systemic hypotension. During the reversal of heparin-induced anticoagulation, the effects of... -
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- Vitamin C Improves The Age-Related Impairment of Endothelium-Dependent Vasodilation in Elderly
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On YK, Kim YS, Oh DY, Choi JO, Hwang ES, Kim CH
- KMID: 2188714
- J Korean Geriatr Soc.
- 2001 Mar;5(1):24-32.
BACKGROUND: Aging is associated with increased cardiovascular risk and firmly established as a risk factor for the development of atherosclerosis. However the exact mechanism of age-related damage to the arterial... -
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- Inhibition of Platelet Aggregation by Mononuclear Leukocytes
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Chang EA, Cha YJ
- KMID: 1849143
- Korean J Hematol.
- 1998 Oct;33(3):398-405.
BACKGROUND: Although normal vascular endothelium prevents adhesion and aggregation of platelets by the release of nitric oxide (NO) and prostacyclin, circulating blood cells, such as polymorphonuclear leukocytes (PMNs) and mononuclear... -
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- Relationship of the Changes in Biogenic Amines to Nitric Oxide and Oxygen Free Radicals During Cerebral Ischemia/Reperfusion
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Moon JS, Jung HS, Kim DG, Kim KH, Lee BC
- KMID: 2066001
- J Korean Neurol Assoc.
- 1995 Dec;13(4):773-787.
Recently oxygen free radicals and nitric oxide (NO) are known to play an important role in neuronal reperfusion injury. This study was aimed to investigate the role of oxygen f... -
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- A Study of Endothelium-dependent Pulmonary Arterial Relaxation and the Role of Nitric oxide on Acute Hypoxic Pulmonary Vasoconstriction in Rats
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In KH, Lee JG, Cho JY, Shim JJ, Kang KH, Yoo SH
- KMID: 2160352
- Tuberc Respir Dis.
- 1994 Jun;41(3):231-238.
- doi: 10.4046/trd.1994.41.3.231
BACKGROUND: Since the demonstration of the fact that vascular relaxation by acetylcholine(Ach) results from the release of relaxing factor from the endothelium, the identity and physiology of this endothelium-derived relaxing... -
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