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Deletion of the Importin-alpha Gene in the Breast Cancer Cell

Song BJ, Kim CS, Jin MO, Kim DH, Moon YH, Kim IS, Oh ST, Chung SS, Lee JH, Song YT

  • KMID: 2095638
  • J Korean Surg Soc.
  • 1999 Jun;56(Suppl):947-956.
BACKGROUND: BRCA1 (breast-cancer gene 1) is a tumor suppressor gene that accounts for nearly all families of both early onset breast and ovarian cancer and about 45% of families with...
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Development of Monoclonal Antibodies Against Human IRF-5 and Their Use in Identifying the Binding of IRF-5 to Nuclear Import Proteins Karyopherin-alpha1 and -beta1

Yeon SI, Youn JH, Lim MH, Lee HJ, Kim YM, Choi JE, Lee JM, Shin JS

PURPOSE: IRF-5 is a direct transducer of virus-mediated and TLR-mediated signaling pathways for the expression of cytokines and chemokines which form homodimers or heterodimers with IRF-7. However, direct IRF-5-specific monoclonal...
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