- The effects of propofol on neurotoxicity induced by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid in rat mixed cortical cultures
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Seo MS, Park SY, Kim KS, Moon BK, Kim JS, Lee SY
- KMID: 2243003
- Korean J Anesthesiol.
- 2008 Nov;55(5):607-612.
- doi: 10.4097/kjae.2008.55.5.607
BACKGROUND: The pattern of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-mediated neurotoxicity (necrosis vs apoptosis) and the neuroprotective effect of propofol on AMPA-mediated neurotoxicity are still unclear. METHODS: Thirteen-day-old primary rat mixed cortical cultures were... -
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- Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats
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Choi MA, Kim N, Park SE, Park BG, Kim MS, Park BR
- KMID: 1437733
- Res Vestib Sci.
- 2012 Dec;11(4):131-137.
BACKGROUND AND OBJECTIVES: Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is... -
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- The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse
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Kwak MJ, Kim JH
- KMID: 2287761
- Korean J Psychopharmacol.
- 2014 Oct;25(4):149-154.
- doi: 10.0000/kjp.2014.25.4.149
Dopamine has long time considered as the main player in drug addiction. However, growing body of literature strongly supports a role for glutamate in addiction. 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors,... -
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- Increases in Effective Cleft Glutamate Concentration During Expression of LTP
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Jung SH, Choi S
- KMID: 1615001
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):113-120.
Long-term potentiation (LTP) at hippocampal CA3-CA1 synapses is often associated with increases in quantal size, traditionally attributed to enhanced availability or efficacy of postsynaptic glutamate receptors. However, augmented quantal size... -
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- Psychiatric Implication for the Regulation of AMPA Receptor
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Oh D, Lee E
- KMID: 2299868
- Korean J Biol Psychiatry.
- 2013 Feb;20(1):1-5.
Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate... -
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- Combined Application of Bicuculline and 4-Aminopyridine-Induced Epileptiform Activity are Resistant to Conventional Anticonvulsants and AMPA in Young Rat Visual Cortex
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Choi BJ
- KMID: 1816508
- J Korean Epilepsy Soc.
- 2006 Jun;10(1):35-40.
PURPOSE: The goal of the present study was to find out whether blockade of GABAergic synaptic transmission by bicuculline (BIC) in the presence of 4-aminopyridine (4-AP) would lead to expression... -
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- Physiological and pharmacological characterization of glutamate and GABA receptors in the retina
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Yang XL, Shen Y, Han MH, Lu T
- KMID: 2071547
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):461-469.
Glutamate and gamma-aminobutyric acid (GABA) are major excitatory and inhibitory neurotransmitters in the vertebrate retina, respectively. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors have been... -
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- Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension
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Lee JH, Choi MA, Choi DO, Kim BK, Hong SM, Park BR
- KMID: 1518518
- J Korean Bal Soc.
- 2007 Jun;6(1):29-35.
Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular... -
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- Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum
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Jeun SH, Cho HS, Kim KJ, Li QZ, Sung KW
- KMID: 2071673
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):209-214.
- doi: 10.4196/kjpp.2009.13.3.209
The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. The purpose of this study was to... -
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- Experimental Study of Initiation of Cortical Spreading Depression by Excitatory Amino Acids Using a New Topical Application Model
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Park JY, Park YK, Chung YG, Chung HS, Lee KC, Lee HK
- KMID: 2010223
- J Korean Neurosurg Soc.
- 1996 Mar;25(3):462-472.
The purpose of this study was, first, to devise a new model for topical application of excitatory amino acids(EAAs) to rat cerebral cortex that successfully and repeatdly initiate the cortical... -
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- In Vitro Effect of Carbamazepine, D-(-)-2-Amino-5-Phosphonopentanoic Acid and 6-Cyano-7-Nitroquinoxaline-Dione on Pentylenetetrazole-Induced Epileptiform Activity in Young Rat Visual Cortex
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Choi BJ
- KMID: 1851944
- J Korean Epilepsy Soc.
- 2005 Dec;9(2):137-142.
PURPOSE: Carbamazepine (CBZ) has little untoward effect in behavior, cognition and psychosocial aspects and commonly used in children. But, CBZ can sometimes worsen tonic-clonic seizures. The goal of the present... -
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- Up-regulation of PSD-95 in the Rat Hippocampal Formation after Chronic Renal Failure
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Jung YW, Moon IS, Choi DH, Ko BH
- KMID: 1510195
- Korean J Anat.
- 2006 Aug;39(4):289-295.
The mechanism of central nervous system (CNS) dysfunction in uremia are multifactorial and only partially characterized. Studies using hippocampal formation (HF) evaluate the relationship between the uremia and memory impairment. Immunoblots with... -
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- Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices
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Kim DK, Lee S, Jung KY, Kim JK, Choi BK
- KMID: 1611486
- Korean J Physiol Pharmacol.
- 2004 Dec;8(6):301-305.
This study examined the effects of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate on basal and electrically-evoked release of acetylcholine (ACh) from the rat hippocampal and striatal slices which... -
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- A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells
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Park JY, Han J, Hong SG
- KMID: 1607524
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):375-379.
Ca2+ influx appears to be important for triggering myoblast fusion. It remains, however, unclear how Ca2+ influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may... -
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- Glutamate Receptor Subunits Gene Expression in Kainate-induced Temporal Lobe Epilpsy Model
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Kim MK, Choi SM, Lee SH, Kim BC, Cho KH, Nam SC, Lee MC
- KMID: 1812914
- J Korean Neurol Assoc.
- 2001 Jan;19(1):36-44.
BACKGROUND: There is considerable controversy about the exact molecular mechanisms of excitatory amino acid receptors in epileptogenesis. METHODS: We used in situ hybridization to examine the hybridization density (HD) of... -
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- Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses
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Jung SH, Choi S
- KMID: 1614994
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):81-86.
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs... -
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- Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord
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Hur SW, Park JM
- KMID: 2285484
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):553-558.
- doi: 10.4196/kjpp.2013.17.6.553
Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spinothalamic tract (STT) neurons... -
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- Antinociceptive Actions of Excitatory Amino Acid Recetor Antagonists in the Spinal Cord of a Rat Model for Neuropathic Pain
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Lee SA, Leem JW, Park ES, Choi EJ, Nam TS, Paik KS
- KMID: 1957218
- J Korean Neurol Assoc.
- 1995 Sep;13(3):438-452.
It has been proposed that excitatory amirio acid (EAA) receptors mediate sensitimtion of central neurons that may play a cruc ial role in the generation of neuropathic pain. We performed... -
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- AMPA Receptor-Induced Neuronal Cell Death in Rat Hippocampus Following Transient Global Ischemia: Relationship to Calpain and Caspase-3 Expression
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Jung Y, Hong S, Ko B
- KMID: 1894520
- Korean J Anat.
- 2003 Feb;36(1):77-88.
A central challenge in ischemia-induced neuronal death research is understanding the mechanisms by which apoptotic or necrotic cascades are initiated and affected. We tested potential roles for AMPA and NMDA receptor... -
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- The Effect of Intrathecal ACEA 2085, Highly Selective AMPA Receptor Antagonist on the Hyperalgesia Observed after Thermal Injury in the Rat
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Jun JH, Yeom JH, Kim YC, Shim JC, Kim KH, Suh JK, Yoo HK
- KMID: 2335845
- J Korean Pain Soc.
- 1999 May;12(1):1-7.
BACKGROUND: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild bum, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized... -
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