- A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis
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Zeng J, Xiao Xq, Zhou Zy
- KMID: 2528222
- Cancer Res Treat.
- 2022 Apr;54(2):525-540.
- doi: 10.4143/crt.2021.373
Purpose Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF... -
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