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Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation

Song GJ, Kim J, Kim JH, Song S, Park H, Zhang ZY, Suk K

Protein tyrosine phosphatases (PTPs) are key regulatory factors in inflammatory signaling pathways. Although PTPs have been extensively studied, little is known about their role in neuroinflammation. In the present study,...
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Diabetes Promotes Myocardial Fibrosis via AMPK/EZH2/PPAR-γ Signaling Pathway

Li SS, Pan L, Zhang ZY, Zhou MD, Chen XF, Qian LL, Dai M, Lu J, Yu ZM, Dang S, Wang RX

Background: Diabetes-induced cardiac fibrosis is one of the main mechanisms of diabetic cardiomyopathy. As a common histone methyltransferase, enhancer of zeste homolog 2 (EZH2) has been implicated in fibrosis progression...
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Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson’s Disease

Qin Y, Jin Zh, Zhang Zy, Chen Kk, Yu X, Yan Hj, Wang Rd, Su Y, Liu Ax, Xi Jn, Fang By

Background and Purpose Orthostatic hypotension (OH) is common in patients with Parkinson’s disease (PD). Early recognition OH is required with sensitive assessments. The purpose of this study was to determine...
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