- IDH2 gene deficiency accelerates unilateral ureteral obstructioninduced kidney inflammation through oxidative stress and activation of macrophages
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Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM
- KMID: 2512957
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):139-146.
- doi: 10.4196/kjpp.2021.25.2.139
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the... -
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