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Short-Term Outcomes of the First in Vivo Gene Therapy for RPE65-Mediated Retinitis Pigmentosa

Kwak JJ, Kim HR, Byeon SH

Here, we report early treatment outcomes of gene therapy for early onset retinitis pigmentosa (RP) (Leber congenital amaurosis) associated with biallelic RPE65 mutation in a 30-year-old female patient. Initially, her...
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Effects of Interleukin-17A on the Early Stages of Arterial Thrombosis in Mice

Park Y, Shim Y, Kwon I, Lee HW, Nam HS, Choi HJ, Heo JH

Purpose: Interleukin (IL)-17A has been suggested to play a role in the growth and organization of thrombi. We examined whether IL-17A plays a role in the early stages of thrombosis...
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Comparison of Clinical Outcomes for Glycopeptides and Beta-Lactams in Methicillin-Susceptible Staphylococcus Aureus Bloodstream Infections

La YJ, Kim HR, Oh DH, Ahn JY, Kim YC

Purpose: This study aimed to provide compelling evidence of anti-staphylococcal beta-lactam use for methicillin-susceptible Staphylococcus aureus bloodstream infection (MSSA BSI). Materials and Methods: We retrospectively collected data on patients with MSSA...
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Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting

Choi YJ, Kim CH, Lee J, Byun MK, Cho JH, Park HJ

Purpose: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. Materials and...
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What Affects Segmental Lordosis of the Surgical Site after Minimally Invasive Transforaminal Lumbar Interbody Fusion?

Kim SH, Hahn BS, Park JY

Purpose: This study was undertaken to identify factors that affect segmental lordosis (SL) after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) by comparing patients whose postoperative SL increased with those...
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Application of Machine Learning Approaches to Predict Postnatal Growth Failure in Very Low Birth Weight Infants

Han JH, Yoon SJ, Lee HS, Park G, Lim J, Shin JE, Eun HS, Park MS, Lee SM

Purpose: The aims of the study were to develop and evaluate a machine learning model with which to predict postnatal growth failure (PGF) among very low birth weight (VLBW) infants. Materials...
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Machine Learning Model for Classifying the Results of Fetal Cardiotocography Conducted in High-Risk Pregnancies

Park TJ, Chang HJ, Choi BJ, Jung JA, Kang S, Yoon S, Kim M, Yoon D

Purpose: Fetal well-being is usually assessed via fetal heart rate (FHR) monitoring during the antepartum period. However, the interpretation of FHR is a complex and subjective process with low reliability....
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Initial Abdominal CT and Laboratory Findings Prior to Diagnosis of Crohn’s Disease in Children

Kang C, Yoon H, Park S, Kim J, Han K, Kim S, Koh H, Lee MJ, Shin HJ

Purpose: To identify initial abdominal computed tomography (CT) and laboratory findings prior to a diagnosis of Crohn’s disease (CD) in children. Materials and Methods: In this retrospective study, patients (≤18 year-old)...
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Does the Suprascapular Nerve Move within the Suprascapular Notch? Biomechanical Perspective Using the Finite Element Method

Yoo YS, Jang Sw, Kim YS, Choi JA, Oh JH, Jeong JY

Purpose: We aimed to analyze changes in suprascapular nerve (SSN) position within the suprascapular notch during in vivo shoulder abduction. Materials and Methods: Three-dimensional models of the shoulder complex were constructed...
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Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy

Xu Z, Hu W, Wang B, Xu T, Wang J, Wei D

Purpose: Nonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases, including obesity and diabetes, and has gradually become the most common cause of chronic liver disease. We investigated...
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Re-Assessment of Applicability of Greulich and Pyle-Based Bone Age to Korean Children Using Manual and Deep Learning-Based Automated Method

Hwang J, Yoon HM, Hwang JY, Kim PH, Bak B, Bae BU, Sung J, Kim HJ, Jung AY, Cho YA, Lee JS

Purpose: To evaluate the applicability of Greulich-Pyle (GP) standards to bone age (BA) assessment in healthy Korean children using manual and deep learning-based methods. Materials and Methods: We collected 485 hand...
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Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice

Yoo D, Chung N, Yoo J, Song CY, Yang C, Youm HW, Lee K, Jun JH, Lee J, Lee JR

Purpose: In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated...
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