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SARS-CoV-2 Variants of Concern

Choi JY, Smith DM

Since the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants...
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Medications and the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases: Use of the Landmark Method

Choi YY, Lee JK, Kim HS, Kim DW, Kim HM, Kang DR

Purpose: This study aimed to determine whether the use of drugs in the treatment of inflammatory bowel disease is related to the risk of colorectal cancer using a Cox proportional...
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A Deep Learning Model with High Standalone Performance for Diagnosis of Unruptured Intracranial Aneurysm

Joo B, Choi HS, Ahn SS, Cha J, Won SY, Sohn B, Kim H, Han K, Kim HP, Choi JM, Lee SM, Kim TG, Lee SK

Purpose: This study aimed to investigate whether a deep learning model for automated detection of unruptured intracranial aneurysms on time-of-flight (TOF) magnetic resonance angiography (MRA) can achieve a target diagnostic...
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Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Yoon T, Ahn SS, Pyo JY, Song JJ, Park YB, Lee SW

Purpose: We investigated whether serum clusterin levels could reflect the current antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-specific indices. Materials and Methods: Fifty-seven patients with AAV and 40 healthy controls were included...
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Characterization of Ferric Chloride-Induced Arterial Thrombosis Model of Mice and the Role of Red Blood Cells in Thrombosis Acceleration

Shim Y, Kwon I, Park Y, Lee HW, Kim J, Kim YD, Nam HS, Park S, Heo JH

Purpose: The ferric chloride (FeCl3)-induced thrombosis model is widely used for thrombosis research. However, it lacks standardization with uncertainty in the exact mechanism of thrombosis. This study aimed to characterize...
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In Vitro Models Mimicking Immune Response in the Skin

Moon S, Kim DH, Shin JU

The skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been...
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Developing a Dementia Platform Databank Using Multiple Existing Cohorts

Kang M, Cheon BK, Hahn MJ, Seo SW, Cho J, Shin SY, Na DL, Cho J, Choi SH, Kang D

This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts...
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Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors

Choi S, Lee SH, Park S, Park SH, Park C, Key J

Purpose: Indocyanine green (ICG) is a promising agent for intraoperative visualization of tumor tissues and sentinel lymph nodes in early-stage gynecological cancer. However, it has some limitations, including a short...
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Regulation of MUC6 Methylation Correlates with Progression of Gastric Cancer

Shi D, Xi Xx

Purpose: This study aimed to investigate the mechanistic downregulation of mucin 6 (MUC6) and its influence on the progression of gastric cancer (GC). Materials and Methods: The expression of MUC6 was...
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Transcatheter Aortic Valve Replacement with Minimal Contrast Dye in Patients with Renal Insufficiency

Choi JY, Hong GR, Hong SJ, Shim CY, Ahn CM, Kim JS, Kim BK, Ko YG, Choi D, Jang Y, Hong MK

Purpose: Concerns have been consistently raised in regards to the considerable amount of contrast dye used during transcatheter aortic valve replacement (TAVR) in patients with renal insufficiency. In the present...
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Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages

Kim SK, Choe JY, Park KY

Purpose: Interleukin-37 (IL-37) is an anti-inflammatory cytokine that inhibits a broad spectrum of inflammatory responses in various human cells, including neutrophils, macrophages, and endothelial cells. The aim of this study...
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Sex-Related Outcomes of Successful Drug-Coated Balloon Treatment in De Novo Coronary Artery Disease

Kun L, Shin ES, Jun EJ, Bhak Y, Garg S, Kim TH, Sohn CB, Choi BJ, Hui L, Yuan SL, Zhi W, Hao J, Zhentao S, Qiang T

Purpose: Although drug-coated balloon (DCB) treatment is known to be effective for de novo lesions, the influence of sex on angiographic and clinical outcomes remains unknown. This study aimed to...
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