- Regenerative therapies as a potential treatment of erectile dysfunction
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Chung DY, Ryu JK, Yin GN
- KMID: 2544030
- Investig Clin Urol.
- 2023 Jul;64(4):312-324.
- doi: 10.4111/icu.20230104
Erectile dysfunction (ED) is the most common sexual dysfunction disease in adult males. ED can be caused by many factors, such as vascular disease, neuropathy, metabolic disturbances, psychosocial causes, and... -
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- Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice
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Yin GN
- KMID: 2530916
- Investig Clin Urol.
- 2022 Jul;63(4):464-474.
- doi: 10.4111/icu.20220038
Purpose: To comprehensively evaluate the effect on angiogenesis of heme-binding protein 1 (Hebp1) in the treatment of diabetes-induced erectile dysfunction. Materials and Methods: Mouse corpus cavernosum endothelial cells and pericytes were... -
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- Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice
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Kwon MH, Choi MJ, Liu FY, Fridayana FR, Niloofar L, Yin GN, Ryu JK
- KMID: 2533656
- Int Neurourol J.
- 2022 Sep;26(3):201-209.
- doi: 10.5213/inj.2244152.076
Purpose: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice. Methods: Eight-week-old C57BL/6 mice were... -
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- Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase
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Ghatak K, Yin GN, Hong SS, Kang JH, Suh JK, Ryu JK
- KMID: 2537107
- World J Mens Health.
- 2022 Oct;40(4):580-599.
- doi: 10.5534/wjmh.210249
Purpose: Diabetes mellitus, one of the major causes of erectile dysfunction, leads to a poor response to phosphodiesterase-5 inhibitors. Heat shock protein 70 (Hsp70), a ubiquitous molecular chaperone, is known... -
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- A Method to Isolate Pericytes From the Mouse Urinary Bladder for the Study of Diabetic Bladder Dysfunction
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Choi MJ, Minh NN, Ock J, Suh JK, Yin GN, Ryu JK
- KMID: 2510840
- Int Neurourol J.
- 2020 Dec;24(4):332-340.
- doi: 10.5213/inj.2040172.086
Purpose: Pericytes surround the endothelial cells in microvessels and play a distinct role in controlling vascular permeability and maturation. The loss of pericyte function is known to be associated with... -
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- Gene expression profiling of mouse cavernous endothelial cells for diagnostic targets in diabetes-induced erectile dysfunction
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Yin GN, Ock J, Choi MJ, Limanjaya A, Ghatak K, Song KM, Kwon MH, Suh JK, Ryu JK
- KMID: 2509862
- Investig Clin Urol.
- 2021 Jan;62(1):90-99.
- doi: 10.4111/icu.20200119
Purpose: To investigate potential target genes associated with the diabetic condition in mouse cavernous endothelial cells (MCECs) for the treatment of diabetes-induced erectile dysfunction (ED). Materials and Methods: Mouse cavernous tissue... -
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- Differential Expression of Nerve Injury-Induced Protein 1 (Ninjurin 1) in In Vivo and In Vitro Models for Diabetic Erectile Dysfunction
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Kim DK, Yin GN, Ryu JK, Suh JK
- KMID: 2061703
- Korean J Urol.
- 2012 Sep;53(9):636-642.
- doi: 10.4111/kju.2012.53.9.636
PURPOSE: Endothelial dysfunction and peripheral neuropathy are important mechanisms responsible for diabetes-induced erectile dysfunction (ED). Nerve injury-induced protein 1 (Ninjurin 1) is known to be related to neuroinflammatory processes and... -
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- Three-Dimensional Reconstruction of Neurovascular Network in Whole Mount Preparations and ThickCut Transverse Sections of Mouse Urinary Bladder
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Nguyen NM, Song KM, Choi MJ, Ghatak K, Limanjaya A, Kwon MH, Chung DY, Ock J, Yin GN, Park CS, Suh JK, Ryu JK
- KMID: 2509589
- World J Mens Health.
- 2021 Jan;39(1):131-138.
- doi: 10.5534/wjmh.190089
Purpose: Proper functional and structural integrity of nervous and vascular system in urinary bladder plays an important role in normal bladder function and the disruption of these structures is known... -
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- Transcriptional profiling of mouse cavernous pericytes under high-glucose conditions: Implications for diabetic angiopathy
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Yin GN, Wu J, Cui Y, Lin C, Shi L, Gao ZL, Suh JK, Ryu JK, Jin HR
- KMID: 2509866
- Investig Clin Urol.
- 2021 Jan;62(1):100-110.
- doi: 10.4111/icu.20200272
Purpose: Penile erection requires integrative interactions between vascular endothelial cells, pericytes, smooth muscle cells, and autonomic nerves. Furthermore, the importance of the role played by pericytes in the pathogenesis of... -
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- Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie’s Disease
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Song KM, Chung DY, Choi MJ, Ghatak K, Nhat Minh N, Limanjaya A, Kwon MH, Ock J, Yin GN, Kim DK, Ryu JK, Suh JK
- KMID: 2506420
- World J Mens Health.
- 2020 Oct;38(4):552-563.
- doi: 10.5534/wjmh.190071
Purpose: To examine the therapeutic effect of Vactosertib, a small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor (activin receptor-like kinase-5, ALK5), in an experimental model of Peyronie’s... -
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- A Simple and Nonenzymatic Method to Isolate Human Corpus Cavernosum Endothelial Cells and Pericytes for the Study of Erectile Dysfunction
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Yin GN, Ock J, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Jin HR, Ryu JK, Suh JK
- KMID: 2465417
- World J Mens Health.
- 2020 Jan;38(1):123-131.
- doi: 10.5534/wjmh.180091
PURPOSE: To establish a simple and nonenzymatic technique to isolate endothelial cells (ECs) and pericytes from human corpus cavernosum tissue and to evaluate the angiogenic ability of the human cavernous... -
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- Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-β1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque
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Kang DH, Yin GN, Choi MJ, Song KM, Ghatak K, Minh NN, Kwon MH, Seong DH, Ryu JK, Suh JK
- KMID: 2419312
- World J Mens Health.
- 2018 May;36(2):139-146.
- doi: 10.5534/wjmh.170005
PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to... -
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