- Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner
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Wijerathne TD, Kim JH, Kim MJ, Kim CY, Chae MR, Lee SW, Lee KP
- KMID: 2455814
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):381-392.
- doi: 10.4196/kjpp.2019.23.5.381
Sperm function and male fertility are closely related to pH dependent K⺠current (KSper) in human sperm, which is most likely composed of Slo3 and its auxiliary subunit leucine-rich repeat-containing... -
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- Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BK(Ca) activator LDD175
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Wijerathne TD, Kim J, Yang D, Lee KP
- KMID: 2371043
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):241-249.
- doi: 10.4196/kjpp.2017.21.2.241
Plasma membrane hyperpolarization associated with activation of Ca²âº-activated K⺠channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2-subunit, LRRC52... -
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