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Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy

Kim H, Kim N, Joo H, Youm JB, Park WS, Warda M, Kang S, Thu VT, Khoa TM, Han J

  • KMID: 1600113
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):299-304.
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we...
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Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart

Thu VT, Cuong DV, Kim N, Youm JB, Warda M, Park WS, Ko JH, Kim E, Han J

  • KMID: 1512908
  • Korean J Physiol Pharmacol.
  • 2007 Apr;11(2):57-64.
Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or...
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Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes

Kang S, Kim N, Joo H, Youm JB, Park WS, Warda M, Kim H, Cuong DV, Kim T, Kim E, Han J

  • KMID: 1600112
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):291-298.
To characterize cytosolic Ca2+ fluctuations under metabolic inhibition, rat ventricular myocytes were exposed to 200microM 2, 4-dinitrophenol (DNP), and mitochondrial Ca2+, mitochondrial membrane potential (delta psi m), and cytosolic Ca2+...
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