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Recent Updates on Narcolepsy and Hypersomnia

Hong S

Narcolepsy is a chronic neurological sleep disorder caused by hypocretin neuron loss, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and intrusions of aspects of rapid eye movement sleep in...
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Dexmedetomidine: present and future directions

Lee S

Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine induces a unique sedative response, which shows an easy transition from sleep...
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Difference in Sleep Characteristics between Restless Leg Syndrome With and Without Periodic Limb Movement during Wakefulness

Shin YY, Byun JI, Shin WC

OBJECTIVES: Restless leg syndrome (RLS) is a common sensorimotor disorder and is frequently associated with periodic limb movement in sleep (PLMS). Also about one third of patient with RLS have...
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The Feasibility for Whole-Night Sleep Brain Network Research Using Synchronous EEG-fMRI

Kim JI, Park B, Youn T, Park HJ

OBJECTIVES: Synchronous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has been used to explore sleep stage dependent functional brain networks. Despite a growing number of sleep studies using EEG-fMRI,...
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Proper administration of psychostimulants

Nam B

Psychostimulants are a broad class of sympathomimetic drugs that include drugs of abuse, such as illegal substances, as well as therapeutic drugs, such as methylphenidate and modafinil. The common effect...
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Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression

Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S

Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been...
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Sleep Disturbances as a Risk Factor for Stroke

Koo DL, Nam H, Thomas RJ, Yun CH

Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during...
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Differential Effect of Light Emitting Diode Light on Electroencephalographic Oscillations in Young and Old Healthy Subjects

Sunwoo JS, Lee S, Cha KS, Kim TJ, Byun JI, Jung KY

OBJECTIVES: To investigate brain oscillatory characteristics according to brightness and color temperature of light emitting diode (LED) light in young and elderly subjects. METHODS: We analyzed 22 young (age, 29.0±5.2 years)...
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Ethanol Extract of Perillae Herba Enhances Pentobarbital-Induced Sleep and Non-Rapid Eye Movement (NREM) Sleep through GABA(A)-ergic Systems

Kwon YO, Ha TW, Oh KW

Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors...
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Maintenance of Wakefulness and Occupational Injuries among Workers of an Italian Teaching Hospital

Valent F, Sincig E, Gigli GL, Dolso P

BACKGROUND: To assess in a laboratory setting the ability to stay awake in a sample of workers of an Italian hospital and to investigate the association between that ability and...
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Light Exposure and Sleep-Wake Pattern in Rapidly Rotating Shift Nurses

Choi SJ, Joo EY

OBJECTIVES: Shift workers are at risk for various sleep and health-related problems. To investigate light exposure and sleep-wake pattern according to shift schedules in shift workers. METHODS: We enrolled 12 full-time,...
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Pupil Size in Relation to Cortical States during Isoflurane Anesthesia

Kum JE, Han HB, Choi JH

In neuronal recording studies on anesthetized animals, reliable measures for the transitional moment of consciousness are frequently required. Previous findings suggest that pupil fluctuations reflect the neuronal states during quiet...
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The Relationship of Caffeine Intake with Depression, Anxiety, Stress, and Sleep in Korean Adolescents

Jin MJ, Yoon CH, Ko HJ, Kim HM, Kim AS, Moon HN, Jung SP

BACKGROUND: In various studies in adults, caffeine may increase wakefulness and relieve pain, but caffeine overdose can cause many adverse serious effects on health. Caffeine intake has recently been increasing...
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Electrophysiological Characteristics of Obstructive Sleep Apnea Syndrome with Insomnia: Polysomnography and Cardiopulmonary Coupling Analysis

Park HR, Joo EY, Hong SB

OBJECTIVES: To characterize sleep of subjects with obstructive sleep apnea syndrome (OSA) with insomnia compared to OSA without insomnia in terms of polysomnography (PSG) and cardiopulmonary coupling (CPC) analysis. METHODS: Subjects...
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Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice

Mabunga DF, Gonzales E, Kim HJ, Choung SY

gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia...
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The Efficacy of Cognitive Behavioral Therapy for Insomnia and Factors Associated with Favorable Outcome

Jung JH, Lee BC, Moon HJ, Cho YW

  • KMID: 2202656
  • J Korean Sleep Res Soc.
  • 2013 Dec;10(2):39-44.
OBJECTIVES: Cognitive behavioral therapy for insomnia (CBT-I) is a treatment for chronic insomnia via psychological intervention. CBT-I is as effective as pharmacotherapy for insomnia patients. This study investigates the clinical...
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Diagnosis of Obstructive Sleep Apnea Syndrome

Chung YS

Obstructive sleep apnea is a prevalent disease and contributes to consequences like hypertension, diabetes, stroke, cardiac disease, daytime sleepiness, decreased productivity, mood change, and quality of life. The mortality and...
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Stress and Sleep Disorder

Han KS, Kim L, Shim I

The purpose of this study was to review potential, physiological, hormonal and neuronal mechanisms that may mediate the sleep changes. This paper investigates the literatures regarding the activity of the...
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Analysis of Interictal Epileptiform Discharges in the Benign Childhood Epilepsy with Centrotemporal Spikes: Prediction of Seizure Outcome

Kim MK, Kim MS, Park C, Byeon JH, Kim GH, Hong YS, Lee JW, Eun BL

  • KMID: 2059494
  • J Korean Child Neurol Soc.
  • 2012 Sep;20(3):144-150.
PURPOSE: The benign childhood epilepsy with centrotemporal spikes (BECTS), commonly affecting children between 3 and 13 years of age, is focal epilepsy with the presence of centrotemporal spikes on electroencephalography...
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Adverse Effects of 24 Hours of Sleep Deprivation on Cognition and Stress Hormones

Joo EY, Yoon CW, Koo DL, Kim D, Hong SB

  • KMID: 2425233
  • J Clin Neurol.
  • 2012 Jun;8(2):146-150.
BACKGROUND AND PURPOSE: The present study was designed to investigate whether 24 h of SD negatively affects the attention and working memory and increases the serum concentrations of stress hormones,...
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