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Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

Kim SH, Jang YS

Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of...
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Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice

Zhao H, Wang Y, Ma Z, Wang Y, Feng WH

Currently, killed-virus and modified-live porcine reproductive and respiratory syndrome virus (PRRSV) vaccines are used to control porcine reproductive and respiratory syndrome. However, both types of vaccines have inherent drawbacks; accordingly,...
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DNA vaccines for cervical cancer: from bench to bedside

Hung CF, Monie A, Alvarez RD, Wu TC

  • KMID: 1091062
  • Exp Mol Med.
  • 2007 Dec;39(6):679-689.
More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves...
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Influence of vaccine potency and booster administration of foot-and-mouth disease vaccines on the antibody response in calves with maternal antibodies

Çokçalışkan C, Türkoğlu T, Uzunlu E, Sareyyüpoğlu B, Hancı I, İpek A, Arslan A, Babak A, İldeniz G, Gülyaz V

Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals. Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions....
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Association of the time that elapsed from last vaccination with protective effectiveness against foot-and-mouth disease in small ruminants

Elnekave E, Even-Tov B, Gelman B, Sharir B, Klement E

Routine and emergency vaccination of small ruminants against foot-and-mouth disease (FMD) is mandatory in many endemic countries, yet data on the field effectiveness of the vaccines used is scarce. We...
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Enhancing mucosal immunity in mice by recombinant adenovirus expressing major epitopes of porcine circovirus-2 capsid protein delivered with cytosine-phosphate-guanosine oligodeoxynucleotides

Chang HT, He XY, Liu YF, Chen L, Guo QH, Yu QY, Zhao J, Wang XW, Yang X, Wang CQ

A recombinant replication-defective adenovirus expressing the major epitopes of porcine circovirus-2 (PCV-2) capsid protein (rAd/Cap/518) was previously constructed and shown to induce mucosal immunity in mice following intranasal delivery. In...
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Immune responses in pigs and cattle vaccinated with half-volume foot-and-mouth disease vaccine

Park ME, You SH, Lee SY, Lee KN, Ko MK, Choi JH, Kim B, Lee JS, Park JH

With the current commercial foot-and-mouth disease vaccine, inoculating twice increases the formation of denatured meat due to granuloma or residual adjuvant at the injection site in pigs, resulting in economic...
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