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HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1

Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK

  • KMID: 755753
  • Exp Mol Med.
  • 2005 Apr;37(2):138-145.
Liver cirrhosis is one of the major complications of hepatitis C virus (HCV) infection, but the mechanisms underlying HCV-related fibrogenesis are still not clear. Although the roles of HCV core...
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Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells

Kim J, Choi BH, Jang KL, Min DS

  • KMID: 1123766
  • Exp Mol Med.
  • 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast...
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