- A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens
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Park JY, Park SY, Kwon H, Song Y, Yun B, Lee Y, Cho Y, Joo A, Han PL
- KMID: 2424733
- Exp Neurobiol.
- 2018 Oct;27(5):387-396.
- doi: 10.5607/en.2018.27.5.387
The nucleus accumbens (NAc) is the major component of the ventral striatum that regulates stress-induced depression. The NAc receives dopaminergic inputs from the ventral tegmental area (VTA), and the role... -
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- Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes
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Nam MH, Han KS, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang E, Bae YC, Lee CJ
- KMID: 2410473
- Exp Neurobiol.
- 2018 Apr;27(2):120-128.
- doi: 10.5607/en.2018.27.2.120
µ-opioid receptor (MOR) is a class of opioid receptors with a high affinity for enkephalins and beta-endorphin. In hippocampus, activation of MOR is known to enhance the neuronal excitability of... -
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- Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition
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Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, Wang F
- KMID: 2440027
- Exp Mol Med.
- 2018 Feb;50(2):e445.
- doi: 10.1038/emm.2017.271
Our previous works disclosed the contributing role of macrophage migration inhibitory factor (MIF) and dopaminergic inhibition by lysine dimethyltransferase G9a/Glp complex in peripheral nerve injury-induced hypersensitivity. We herein propose that... -
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- Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake
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Yoon YR, Baik JH
- KMID: 2169668
- Endocrinol Metab.
- 2015 Dec;30(4):576-583.
- doi: 10.3803/EnM.2015.30.4.576
BACKGROUND: The melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food... -
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- How Leptin Controls the Drive to Eat
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Patterson , Myers MG
- KMID: 2271158
- Korean J Obes.
- 2015 Jun;24(2):69-77.
A complex set of brain based systems modulate feeding to maintain constant body weight. The adipose derived-hormone, leptin, plays a crucial role in this control by acting on diverse leptin... -
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- Acamprosate-induced Extrapyramidal Symptoms in an Elderly Patient with Alcohol Dependence
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Woo J, Rim HD
- KMID: 2279951
- Clin Psychopharmacol Neurosci.
- 2014 Aug;12(2):166-168.
Acamprosate reduces the craving for alcohol by decreasing glutamate activity and increasing gamma-aminobutyric acid (GABA) action in patients with alcohol dependence. Acamprosate has tolerable side effects that include diarrhea, headache,... -
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- Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats
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Lee B, Sur B, Park J, Kim SH, Kwon S, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 1500233
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):393-403.
- doi: 10.4196/kjpp.2013.17.5.393
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated... -
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- Neurobiology, pharmacokinetics and pharmacodynamics of drug abuse
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Kim SY, Lee JS, Han DW
- KMID: 2015672
- J Korean Med Assoc.
- 2013 Sep;56(9):762-770.
- doi: 10.5124/jkma.2013.56.9.762
All drugs of abuse, like neural rewarding behaviors such as sex and eating, increase extra-cellular dopamine (DA) levels in the nucleus accumbens (NA), which is a part of the common... -
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- Beyond Substance Addiction: Broadening the Concept of Addiction to Include Behavioral Addiction
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Kim JH, Seo JS
- KMID: 1777548
- J Korean Med Sci.
- 2013 May;28(5):646-647.
- doi: 10.3346/jkms.2013.28.5.646
No abstract available. -
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- Transcriptional Mechanisms of Drug Addiction
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Nestler EJ
- KMID: 1432535
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):136-143.
- doi: 10.9758/cpn.2012.10.3.136
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to... -
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- Etiology and Clinical Charateristics of Alcohol Use Disorder
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Seo JS
- KMID: 2059863
- J Korean Diabetes.
- 2012 Jun;13(2):76-80.
- doi: 10.4093/jkd.2012.13.2.76
Alcohol use disorder (AUD) includes alcohol abuse and alcohol dependence. Since AUD is considered a bio-psycho-social disease, the etiology is multifactorial, including biological, psychological and social variables. Neurobiologically, addiction is... -
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- Smoking as an Addictive Disorder
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Joe KH, Kim DJ
- KMID: 2341546
- J Korean Neuropsychiatr Assoc.
- 2009 Jul;48(4):213-219.
Nicotine is the major substance that accounts for the addictive nature of smoking. Nicotine induces neurobiological and behavioral responses through diverse neurochemical mechanisms over the central nervous system. The brain... -
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- Effects of Repeated Nicotine Treatment on the Changes in Glutamate Receptor Subunits Levels in Mesocorticolimbic Dopamine Areas
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Lee KJ, Kim DH, Choi SH, Shin YC, Park SH, Moon BH, Kang SW, Cho E, Choi SH, Chun BG, Lee MS, Shin KH
- KMID: 1512893
- Korean J Physiol Pharmacol.
- 2007 Aug;11(4):139-144.
Recent studies suggest that alterations in glutamate receptor subunit levels in mesocorticolimbic dopamine areas could account for neural adaptations in response to psychostimulant drugs. Although many drugs of abuse induce... -
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- Neuroanatomy of Sleep-Wake Regulation and its Application to Pharmacotherapy
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Kim HC
- KMID: 2286720
- Korean J Psychopharmacol.
- 2007 May;18(3):133-142.
A current hypothesis of sleep-wake regulation proposes that the sleep process starts with the activation of sleep-promoting neurons located in the preoptic area of the anterior hypothalamus. This activation leads... -
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- Effects of Chronic Alcohol Exposure on Dopaminergic and Serotonergic Neurotransmission System in Rat
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Park SW, Lee YC, Ha EK, Kim YK, Lee YK, Chung DO, Ryu JW, Kong BG, Kim YH
- KMID: 2287358
- Korean J Psychopharmacol.
- 2005 Jan;16(1):81-90.
OBJECTIVE: This study investigates the effects of chronic alcohol exposure on rat brain THmRNA expression, TH (tyrosine hydroxylase) acitivity, and TPH (tryptophan hydroxylase) activity which are important in synthesis of... -
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- The Behavioral Changes and the Patterns of Dopamine NeuronalDegeneration after Intrastriatal 6-hydroxydopamine Injection in Rat
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Lee WY, Kim GM, Lee JI
- KMID: 2342860
- J Korean Neurol Assoc.
- 2000 Nov;18(6):741-747.
BACKGROUND: The terminal destruction of the striatal dopaminergic axon can produce the retrograde degeneration of nigral dopaminergic neurons. An analyses of the postsynaptic dopamine D1 & D2 receptors and the... -
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- The study of dopaminergic immunoreactive cell change in mesencephalon and pons of mongolian gerbil by water deprived day
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Song CW, Lee KY, Park IK, Jung JY, Kwon HJ, Lee CH, Hyun BH, Jung YG, Lee KI, Kim MK
- KMID: 2092725
- Korean J Anat.
- 2000 Apr;33(2):161-171.
Mongolian gerbil (Meriones unguiculatus) has been as an model animal for studing the neurologic disease because of the long-term survival in the condition of water-deprived desert condition. In order to... -
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- The Effect of MPTP on Movement and TH-immunoreactive Neuronal Changes of C57BL/6 Mice in Relation to Aging
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Kim JW, Baek SY, Yoon HW
- KMID: 1530497
- Korean J Anat.
- 1999 Jun;32(3):421-424.
The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on movement and tyrosine hydroxylase (TH)-immunoreactive (ir) neuronal changes in young (5~6 weeks) and aged (10~12 months) C57BL/6 mice were studied. Locomotor... -
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- An Autoradiographic Study on the Rat Neostriatal Dopamine Receptor Changes after 6-hydroxydopamine Injection into the Medial Prefrontal Cortex
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Kwon JS, Lee DY, Woo JI
- KMID: 2340296
- J Korean Neuropsychiatr Assoc.
- 1999 Mar;38(2):408-418.
The frontal cortex of rat is innervated by dopaminergic pathway(mesocortical pathway) arising from ventral tegmental area. Several studies have suggested that mesocortical dopaminergic neurons may modulate the function of dopaminergic... -
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- Distribution of Brain-Derived Neurotrophic Factor-Immunoreactive Neurons and Axon Terminals in the Rat Brain
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Lee SW, Kim JK, Kim DS, Cho HJ
- KMID: 1530291
- Korean J Anat.
- 1998 Dec;31(6):871-885.
Because of its broad range of activities, BDNF is being tested or considered for treatment of a variety of neurodegen-erative diseases. However, a discrepancy exists in the literature concerning the... -
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