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The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease

Nicolaides S, Vasudevan A, Long T, van Langenberg D

Smoking significantly increases the risk of developing and worsens Crohn’s disease (CD), yet protects against the development and reduces the severity of ulcerative colitis. It is less clear whether smoking...
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Assessing quality of magnetic resonance enterography and its impact on disease assessment of ileal Crohn’s disease

Bohra A, Connoley DJ, Con D, Segal JP, Niewiadomski O, Vasudevan A, Langenberg DRV, Kutaiba N

Background/Aims: Assessment of quality of magnetic resonance enterography (MRE) in small bowel Crohn’s disease (CD) activity evaluation has received little attention. We assessed the impact of bowel distention and motion...
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Biomarker dynamics during infliximab salvage for acute severe ulcerative colitis: C-reactive protein (CRP)-lymphocyte ratio and CRP-albumin ratio are useful in predicting colectomy

Con D, Andrew B, Nicolaides S, van Langenberg DR, Vasudevan A

Background/Aims: The residual risk of colectomy after infliximab salvage in steroid-refractory acute severe ulcerative colitis (ASUC) is required to inform the need for subsequent maintenance biologic therapy. The aim of...
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Expression profiling of cultured podocytes exposed to nephrotic plasma reveals intrinsic molecular signatures of nephrotic syndrome

Panigrahi S, Pardeshi VC, Chandrasekaran K, Neelakandan K, PS H, Vasudevan A

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes,...
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