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Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models

Kim SH, Choi KC

  • KMID: 2317840
  • Toxicol Res.
  • 2013 Dec;29(4):229-234.
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long times, phytoestrogens have been used for therapeutic treatments against human diseases, and they can be promising ingredients...
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Assessment of Developmental Toxicants using Human Embryonic Stem Cells

Hong EJ, Jeung EB

  • KMID: 2317839
  • Toxicol Res.
  • 2013 Dec;29(4):221-227.
Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid...
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Genotoxicity Assessment of Erythritol by Using Short-term Assay

Chung YS, Lee M

  • KMID: 2317843
  • Toxicol Res.
  • 2013 Dec;29(4):249-255.
Erythritol is a sugar alcohol that is widely used as a natural sugar substitute. Thus, the safety of its usage is very important. In the present study, short-term genotoxicity assays...
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Real-time Assay of Toxic Lead in In Vivo Living Plant Tissue

Ly S, Kim NJ, Youn M, Kim Y, Sung Y, Kim D, Chung T

  • KMID: 2317848
  • Toxicol Res.
  • 2013 Dec;29(4):293-298.
A method of detecting lead was developed using square wave anodic stripping voltammetry (SWASV) with DNA-carbon nanotube paste electrode (CNTPE). The results indicated a sensitive oxidation peak current of lead...
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Subacute Oral Toxicity Study of Korean Red Ginseng Extract in Sprague-Dawley Rats

Park SJ, Lim KH, Noh JH, Jeong EJ, Kim YS, Han BC, Lee SH, Moon KS

  • KMID: 2317847
  • Toxicol Res.
  • 2013 Dec;29(4):285-292.
Ginseng is a well-known traditional medicine used in Asian countries for several thousand years, and it is currently applied to medicine, cosmetics, and nutritional supplements due to its many healing...
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Cytotoxic Activity from Curcuma zedoaria Through Mitochondrial Activation on Ovarian Cancer Cells

Shin Y, Lee Y

  • KMID: 2317844
  • Toxicol Res.
  • 2013 Dec;29(4):257-261.
alpha-Curcumene is one of the physiologically active components of Curcuma zedoaria, which is believed to perform anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we...
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Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai

Hong CE, Lyu SY

  • KMID: 2317846
  • Toxicol Res.
  • 2013 Dec;29(4):279-283.
Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment...
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Mercury induced the Accumulation of Amyloid Beta (Abeta) in PC12 Cells: The Role of Production and Degradation of Abeta

Song JW, Choi BS

  • KMID: 2317841
  • Toxicol Res.
  • 2013 Dec;29(4):235-240.
Extracellular accumulation of amyloid beta protein (Abeta) plays a central role in Alzheimer's disease (AD). Some metals, such as copper, lead, and aluminum can affect the Abeta accumulation in the...
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Action Mechanism of Chamaecyparis obtusa Oil on Hair Growth

Park YO, Kim SE, Kim YC

  • KMID: 2317842
  • Toxicol Res.
  • 2013 Dec;29(4):241-247.
This study was carried out to examine the action mechanism of Chamaecyparis obtusa oil (CO) on hair growth in C57BL/6 mice. For alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (gamma-GT) activities...
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Evaluation of General Toxicity and Genotoxicity of the Silkworm Extract Powder

Heo HS, Choi JH, Oh JJ, Lee WJ, Kim SS, Lee DH, Lee HK, Song SW, Kim KH, Choi YK, Ryu KS, Kang BH

  • KMID: 2317845
  • Toxicol Res.
  • 2013 Dec;29(4):263-278.
The silkworm extract powder contain 1-deoxynojirimycin (DNJ), a potent alpha-glycosidase inhibitor, has therapeutic potency against diabetes mellitus. Therefore, natural products containing DNJ from mulberry leaves and silkworm are consumed as...
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