- Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges
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Lee JY, Kim HS
- KMID: 2519206
- Tissue Eng Regen Med.
- 2021 Aug;18(4):479-484.
- doi: 10.1007/s13770-021-00365-w
The ultimate goal of regenerative medicine is to regain or restore the damaged or lost function of tissues and organs. Several therapeutic strategies are currently being explored to achieve this... -
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- Engineering of Extracellular Vesicles Based on Payload Changes for Tissue Regeneration
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Park DJ, Seo YJ
- KMID: 2519207
- Tissue Eng Regen Med.
- 2021 Aug;18(4):485-497.
- doi: 10.1007/s13770-021-00349-w
In the field of tissue regeneration and tissue engineering, many years ago, various nano to macroscopic-sized materials have been used to reduce inflammation and restore damaged tissue. Whether it is... -
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- Liver Organoids: Formation Strategies and Biomedical Applications
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Zhu X, Zhang B, He Y, Bao J
- KMID: 2519214
- Tissue Eng Regen Med.
- 2021 Aug;18(4):573-585.
- doi: 10.1007/s13770-021-00357-w
The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only... -
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- Intra-Articular Atelocollagen Injection for the Treatment of Articular Cartilage Defects in Rabbit Model
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Suh DS, Yoo JC, Woo SH, Kwak AS
- KMID: 2519220
- Tissue Eng Regen Med.
- 2021 Aug;18(4):663-670.
- doi: 10.1007/s13770-021-00337-0
BACKGROUND: Atelocollagen is widely recognized as a biomaterial for regenerative medicine because of its good compatibility and low antigenicity. Injury of the outermost layer of articular cartilage, known as the... -
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- Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes
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Choi H, Choi Y, Yim HY, Mirzaaghasi A, Yoo JK, Choi C
- KMID: 2519208
- Tissue Eng Regen Med.
- 2021 Aug;18(4):499-511.
- doi: 10.1007/s13770-021-00361-0
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules for intercellular communication. Due to their therapeutic potential, exosomes have been engineered in numerous ways for efficient delivery of active... -
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- Optimizing Decellularization Strategies for the Efficient Production of Whole Rat Kidney Scaffolds
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Mallis P, Oikonomidis C, Dimou Z, Stavropoulos-Giokas C, Michalopoulos E, Katsimpoulas M
- KMID: 2519217
- Tissue Eng Regen Med.
- 2021 Aug;18(4):623-640.
- doi: 10.1007/s13770-021-00339-y
BACKGROUND: Renal dysfunction remains a global issue, with chronic kidney disease being the 18th most leading cause of death, worldwide. The increased demands in kidney transplants, led the scientific society... -
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- Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing
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Heo JS, Kim S, Yang CE, Choi Y, Song SY, Kim HO
- KMID: 2519211
- Tissue Eng Regen Med.
- 2021 Aug;18(4):537-548.
- doi: 10.1007/s13770-020-00316-x
Background: Human adipose-derived mesenchymal stem cells (AMSCs) are an attractive resource for wound healing because their regenerative capacity improves injury repair. Recently, stem cell-derived exosomes have been shown to play a... -
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- Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes
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Hui L, Shoumei X, Zhoujing Z, Kuang G, Duohong Z, Jiacai H, Yong Z
- KMID: 2519218
- Tissue Eng Regen Med.
- 2021 Aug;18(4):641-650.
- doi: 10.1007/s13770-021-00358-9
BACKGROUND: The role of sex hormones and their receptors has drawn much attention in the process of cartilage regeneration. This study aimed to investigate the effect of androgen receptor (AR)... -
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- PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid NeutralizationMediated Anti-Inflammation
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Kim JK, Go EJ, Ko KW, Oh HJ, Han J, Han DK, Park W
- KMID: 2519216
- Tissue Eng Regen Med.
- 2021 Aug;18(4):613-522.
- doi: 10.1007/s13770-021-00338-z
BACKGROUND: Poly(lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using... -
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- Strategies to Enhance Extracellular Vesicle Production
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Hahm J, Kim J, Park J
- KMID: 2519209
- Tissue Eng Regen Med.
- 2021 Aug;18(4):513-524.
- doi: 10.1007/s13770-021-00364-x
Extracellular vesicles (EVs) are sub-micrometer lipid vesicles secreted from parental cells with their information such as DNA, RNA, and proteins. EVs can deliver their cargo to recipient cells and regulate... -
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- Mesenchymal Stem Cell Transplantation for Ischemic Diseases: Mechanisms and Challenges
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Van Nguyen TT, Vu NB, Pham PV
- KMID: 2519215
- Tissue Eng Regen Med.
- 2021 Aug;18(4):587-611.
- doi: 10.1007/s13770-021-00334-3
Ischemic diseases are conditions associated with the restriction or blockage of blood supply to specific tissues. These conditions can cause moderate to severe complications in patients, and can lead to... -
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- The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing
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Kim MK, Choi YC, Cho SH, Choi JS, Cho YW
- KMID: 2519213
- Tissue Eng Regen Med.
- 2021 Aug;18(4):561-571.
- doi: 10.1007/s13770-021-00367-8
Background: Extracellular vesicles (EVs) derived from plants have emerged as potential candidates for cosmetic and therapeutic applications. In this study, we isolated EVs from Aloe vera peels (A-EVs) and investigated the... -
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- Rapid Differentiation of Human Embryonic Stem Cells into Testosterone-Producing Leydig Cell-Like Cells In vitro
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Shin EY, Park S, Choi WY, Lee DR
- KMID: 2519219
- Tissue Eng Regen Med.
- 2021 Aug;18(4):651-662.
- doi: 10.1007/s13770-021-00359-8
BACKGROUND: Leydig cells (LCs) are testicular somatic cells that are the major producers of testosterone in males. Testosterone is essential for male physiology and reproduction. Reduced testosterone levels lead to hypogonadism... -
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- Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect
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Choi YS, Ham DS, Lim JY, Lee YK
- KMID: 2519221
- Tissue Eng Regen Med.
- 2021 Aug;18(4):671-683.
- doi: 10.1007/s13770-021-00340-5
Background: Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by... -
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- Mesenchymal Stromal Cell-Derived Extracellular Vesicles Pass through the Filtration Barrier and Protect Podocytes in a 3D Glomerular Model under Continuous Perfusion
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Bellucci L, Montini G, Collino F, Bussolati B
- KMID: 2519212
- Tissue Eng Regen Med.
- 2021 Aug;18(4):549-560.
- doi: 10.1007/s13770-021-00374-9
BACKGROUND: Dynamic cultures, characterized by continuous fluid reperfusion, elicit physiological responses from cultured cells. Mesenchymal stem cell-derived EVs (MSC-EVs) has been proposed as a novel approach in treating several renal... -
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- Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration
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Wu J, Yang Q, Wu S, Yuan R, Zhao X, Li Y, Wu W, Zhu N
- KMID: 2519222
- Tissue Eng Regen Med.
- 2021 Aug;18(4):685-691.
- doi: 10.1007/s13770-021-00347-y
BACKGROUND: Some scholars have found that dermal papilla spheroid–derived exosomes could promote the development of hair follicles. However, whether adipose-derived stem cell exosomes (ADSC-Exos) have a similar effect on hair... -
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- Exosomes from IL-1b-Primed Mesenchymal Stem Cells Inhibited IL-1b- and TNF-a-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells
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Kim M, Shin DI, Choi BH, Min BH
- KMID: 2519210
- Tissue Eng Regen Med.
- 2021 Aug;18(4):525-536.
- doi: 10.1007/s13770-020-00324-x
BACKGROUND: Exosomes from mesenchymal stem cells (MSCs) show anti-inflammatory effect on osteoarthritis (OA); however, their biological effect and mechanism are not yet clearly understood. This study investigated the anti-inflammatory effect and... -
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