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Role of Estrogen Receptor-alpha in the Regulation of Claudin-6 Expression in Breast Cancer Cells

Yafang L, Qiong W, Yue R, Xiaoming X, Lina Y, Mingzi Z, Ting Z, Yulin L, Chengshi Q

PURPOSE: In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17beta-estradiol induces a concentration- and time-related effect on CLDN6 mRNA...
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The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation

Ji SY, Ting Z, Noh AL, Moon M, Yim M

OBJECTIVES: Osteoclasts (OCs) are bone-resorbing multinucleated cells derived from hematopoietic progenitors of the monocyte-macrophage lineage. OC precursors, such as bone marrow-derived macrophages (BMMs), are formed in the presence of macrophage...
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