- Ketogenic Diet in Infants with Early-Onset Epileptic Encephalopathy and SCN2A Mutation
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Tian X, Zhang Y, Zhang J, Lu Y, Men X, Wang X
- KMID: 2514104
- Yonsei Med J.
- 2021 Apr;62(4):370-373.
- doi: 10.3349/ymj.2021.62.4.370
Research has shown mutations in the voltage-gated sodium channel gene SCN2A to be associated with developmental delays and infantile seizures in patients with early-onset epileptic encephalopathies (EOEEs). Here, we report... -
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- m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis
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Ming Y, Deng Z, Tian X, Jia Y, Ning M, Cheng S
- KMID: 2535964
- Psychiatry Investig.
- 2022 Oct;19(10):771-787.
- doi: 10.30773/pi.2021.0370
Objective Hippocampal neuron apoptosis contributes to autism, while METTL3 has been documented to possess great potentials in neuron apoptosis. Our study probed into the role of METTL3 in neuron apoptosis... -
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- Nuclear Magnetic Resonance Analysis Implicates Sex-Specific Dysregulation of the Blood Lipids in Alzheimer’s Disease: A Retrospective Health-Controlled Study
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Li Y, Yu X, Ma Z, Liu Q, Li M, Tian X, Li B, Zhang R, Gu P, Bai F, Luo G, Li M, Sun D
- KMID: 2560893
- Psychiatry Investig.
- 2024 Nov;21(11):1211-1220.
- doi: 10.30773/pi.2024.0164
Objective The aging demographic landscape worldwide portends a heightened prevalence of neurodegenerative disorders. Foremost among these is Alzheimer’s disease (AD), the foremost cause of dementia in older adults. The shortage... -
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- Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia
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Nan J, Zhang L, Zhu F, Tian X, Zheng Q, von Deneen KM, Liu J, Zhang M
- KMID: 2379711
- J Neurogastroenterol Motil.
- 2016 Jan;22(1):118-128.
- doi: 10.5056/jnm15118
BACKGROUND/AIMS: Previous studies reported that integrated information in the brain ultimately determines the subjective experience of patients with chronic pain, but how the information is integrated in the brain connectome... -
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- Meta-Analysis of the SLCO1B1 c.521T>C Variant Reveals Slight Influence on the Lipid-Lowering Efficacy of Statins
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Dou Y, Zhu X, Wang Q, Tian X, Cheng J, Zhang E
- KMID: 2363205
- Ann Lab Med.
- 2015 May;35(3):329-335.
- doi: 10.3343/alm.2015.35.3.329
BACKGROUND: Several studies have focused on the association between the lipid-lowering efficacy of statins and the SLCO1B1 c.521T>C polymorphism; however, the results are conflicting. The effects of statins show significant... -
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- Antiviral effects of Bovine antimicrobial peptide against TGEV in vivo and in vitro
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Liang X, Zhang X, Lian K, Tian X, Zhang M, Wang S, Chen C, Nie C, Pan Y, Han F, Wei Z, Zhang W
- KMID: 2507280
- J Vet Sci.
- 2020 Sep;21(5):e80.
- doi: 10.4142/jvs.2020.21.e80
Background: In suckling piglets, transmissible gastroenteritis virus (TGEV) causes lethal diarrhea accompanied by high infection and mortality rates, leading to considerable economic losses. This study explored methods of preventing or... -
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- Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain
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Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG
- KMID: 2361516
- Exp Mol Med.
- 2016 Apr;48(4):e229.
- doi: 10.1038/emm.2016.13
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological... -
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