- The Effect of Diphenyl Dimethyl Dicarboxylate on Thioacetamide Treated Acute Hepatic Injury
-
Lee HJ, Choi JH, Choi HC, Ha JH, Suh JI
- KMID: 2306369
- Korean J Med.
- 1998 Jun;54(6):804-813.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Pentoxifylline on Liver Fibrosis and Cell Cycle Related Proteins in Thioacetamide-Induced Rat Cirrhosis
-
Jang KT, Lee MS, Jung IP, Kim MR, Jang JJ
- KMID: 1890004
- Korean J Hepatol.
- 2001 Sep;7(3):281-291.
Background: Thioacetamide is a classic hepatotoxic reagent which leads to the reproducible hepatic fibrosis in rats. Thioacetamide-induced fibrosis is an appropriate model for cirrhosis in humans due to the long... -
- CITED
-
- Close
- SHARE
-
- Close
- Hepatic Asialoglycoprotein Receptor Scintigraphy Using 99mTc - Galactosylated Serum Albumin ( GSA ): Biodistribution Study in Mice with Thioacetamide - induced Hepatic Injury
-
Hyun DW, Lee JT, Chun KA, Lee SW, Kim SK, Kang DY, Kwon YO, Sohn YK, Lee KB, Chung JM
- KMID: 2143304
- Korean J Hepatol.
- 1998 Jun;4(2):151-161.
BACKGROUND/AIMS: Tc-DTPA-galactosylated serum albumin (GSA) is a new liver imaging agent that specifically binds to asialoglycoprotein receptor, which resides exclusively on the plasma membrane of mammalian hepatocytes. To evaluate the usefulness of... -
- CITED
-
- Close
- SHARE
-
- Close
- Protective Effects of Diallyl Sulfide against Thioacetamide-Induced Toxicity: A Possible Role of Cytochrome P450 2E1
-
Kim NH, Lee S, Kang MJ, Jeong HG, Kang W, Jeong TC
- KMID: 2170655
- Biomol Ther.
- 2014 Mar;22(2):149-154.
Effects of diallyl sulfide (DAS) on thioacetamide-induced hepatotoxicity and immunotoxicity were investigated. When male Sprague-Dawley rats were treated orally with 100, 200 and 400 mg/kg of DAS in corn oil... -
- CITED
-
- Close
- SHARE
-
- Close
- Animal Models of Acute Hepatic Failure
-
Hwang SG
- KMID: 2084977
- Korean J Gastroenterol.
- 2001 May;37(5):303-311.
Our understanding and treatment of acute hepatic failure have been limited by the lack of satisfactory animal models. The requirements for a satisfactory animal models are reversibility, reproducibility, death from... -
- CITED
-
- Close
- SHARE
-
- Close
- Animal Models for Biliary Diseases
-
Kim JS
- KMID: 2168078
- Hanyang Med Rev.
- 2007 Feb;27(1):13-19.
Using animal models for the study of biliary disease is useful not only in promoting insight in its pathogenesis, but also in developing new therapeutic agents in various biliary diseases.... -
- CITED
-
- Close
- SHARE
-
- Close
- Glucose-6-phosphatase Activity and Ultrastructures in Hepatocytes of Thioacetamide-treated Mice
-
Shin TS, Deung YK, Kim SS
- KMID: 687717
- Yonsei Med J.
- 1976 Dec;17(2):85-96.
- doi: 10.3349/ymj.1976.17.2.85
To investigate the earlier cellular alterations(Glucose-6-Pase activity and morphologic features) caused by a hepatotoxin, thioacetamide (TAA), a single dose of the agent (200mg per kg of body weight) was given... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Thioacetamide-Induced Chronic Liver Injury
-
Park SY, Shin HW, Lee KB, Lee MJ, Jang JJ
- KMID: 1792927
- J Korean Med Sci.
- 2010 Apr;25(4):570-576.
- doi: 10.3346/jkms.2010.25.4.570
Hepatic fibrogenesis, a complex process that involves a marked accumulation of extracellular matrix components, activation of cells capable of producing matrix materials, cytokine release, and tissue remodeling, is regulated by... -
- CITED
-
- Close
- SHARE
-
- Close
- Altered remodeling of nucleolar machineries in cultured hepatocytes treated with thioacetamide
-
Jeong JS, Han SY, Kim YH, Choi YC
- KMID: 1066498
- J Korean Med Sci.
- 2001 Feb;16(1):75-82.
- doi: 10.3346/jkms.2001.16.1.75
Thioacetamide (TA) is converted into a hyperacetylating agent which causes hepatic necrosis, regeneration, cirrhosis and cancerous transformation. One of the most characteristic toxicities of TA in rat is observed with... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Active Hexose Correlated Compounds on Drug Induced Liver Injury in Mice
-
Min KO, Kwon HJ, Seo EJ, Kim J, Kang SJ, Kim BK
- KMID: 1725704
- Korean J Pathol.
- 2000 Jul;34(7):509-515.
AHCC (Active Hexose Correlated Compounds), which was at first extracted from cultured broth of Basidiomycotina, is known to be one of the Biological Response Modifiers (BRM). We examined the protective... -
- CITED
-
- Close
- SHARE
-
- Close
- Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
-
Kim IH, Kim SW, Kim SH, Lee SO, Lee ST, Kim DG, Lee MJ, Park WH
- KMID: 1397449
- Exp Mol Med.
- 2012 Jul;44(7):448-456.
Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate... -
- CITED
-
- Close
- SHARE
-
- Close
- Therapeutic potentials occurring during the early differentiation process of mesenchymal stem cells in a rats model with thioacetamide-induced liver fibrosis
-
Choi ST, Hwang S, Hong HN, Won YJ, Ahn CS, Ha TY, Song GW, Jung DH, Park GC, Lee SG
- KMID: 2243165
- Korean J Hepatobiliary Pancreat Surg.
- 2013 Feb;17(1):21-33.
- doi: 10.14701/kjhbps.2013.17.1.21
BACKGROUNDS/AIMS: Mesenchymal stem cells (MSCs) have the capacity to differentiate into hepatocytes, The purpose of this study is to investigate the MSCs' differentiation process and therapeutic potentials by comparing isolated... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide
-
Kim KT, Han SY, Jeong JS
- KMID: 760708
- Korean J Hepatol.
- 2007 Mar;13(1):81-90.
BACKGROUND/AIMS: Eukaryotic cell cycle is regulated by signal transduction pathways mediated by complexes of cyclin dependent kinases (CDKs) and their partner cyclins, or by interaction with CDK inhibitors. Thioacetamide... -
- CITED
-
- Close
- SHARE
-
- Close
- Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway
-
Jeong JS, Kim IH, Lee HJ, Choi YC
- KMID: 755010
- Exp Mol Med.
- 1998 Dec;30(4):205-213.
Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer... -
- CITED
-
- Close
- SHARE
-
- Close
- Protein Expression Profiles in a Rat Cirrhotic Model Induced by Thioacetamide
-
An JH, Seong J, Oh H, Kim W, Han KH, Paik YH
- KMID: 760634
- Korean J Hepatol.
- 2006 Mar;12(1):93-102.
BACKGROUND/AIMS: The reactive oxygen species from thioacetamide (TAA) induces rat liver cirrhosis that resembles the human disease, and it can serve as a suitable animal model for studying human... -
- CITED
-
- Close
- SHARE
-
- Close
- The Factors Affecting Transplanted Hepatocytes Repopulation in Rats with Liver Fibrosis
-
Lee SW, Min SO, Choi SB, Kim KS
- KMID: 1469755
- Korean J Hepatobiliary Pancreat Surg.
- 2009 Dec;13(4):189-197.
PURPOSE: Cell therapy for various diseases has gained wide acceptance. Because most patients with chronic liver failure have mild-to-severe liver cirrhosis, there are many limitations to clinical applications. We analyzed... -
- CITED
-
- Close
- SHARE
-
- Close
- The development of an efficient rat hepatic cirrhosis model
-
Cui FJ, Choi SB, Cho JA, Lee JY, Kim KS, Cho CH, Kim BR
- KMID: 1928371
- Korean J Hepatobiliary Pancreat Surg.
- 2007 Jun;11(2):46-52.
INTRODUCTION: Applying clinical conditions to on experimental animals forto verifverifyingy the mechanism of disease and drug effects is crucial. Cirrhotic livers induced by Hepatitis B virus are frequent, and eEspecially... -
- CITED
-
- Close
- SHARE
-
- Close
- Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver
-
Hong SH, Lee GD, Chung JY, Cho KS, Park SH, Kim IH, Jeong JS
- KMID: 755208
- Exp Mol Med.
- 2002 Nov;34(5):361-366.
Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of... -
- CITED
-
- Close
- SHARE
-
- Close
- Biodistribution of (99m) Tc-Lactosylated Serum Albumin in Mice with Diethylnitrosamine or Thiacetamide Induced Liver Injury
-
Whang JS, Ahn BC, Sung YO, Seo JH, Bae JH, Jeong SY, Yoo JS, Jeong JM, Lee J, Lee KB
- KMID: 2078820
- Korean J Nucl Med.
- 2005 Jun;39(3):200-208.
PURPOSE: Tc-99m labeled diethylenetriaminepentaacetic acid (DTPA) -coupled galactosylated human serum albumin (GSA) is a currently used imaging agent for asialoglycoprotein receptor (ASGPR) of the liver, but, it has several shortcomings.... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-fibrotic effects of Orostachys japonicus A. Berger (Crassulaceae) on hepatic stellate cells and thioacetamide-induced fibrosis in rats
-
Koppula S, Yum MJ, Kim JS, Shin GM, Chae YJ, Yoon T, Chun CS, Lee JD, Song M
- KMID: 2395301
- Nutr Res Pract.
- 2017 Dec;11(6):470-478.
- doi: 10.4162/nrp.2017.11.6.470
BACKGROUND/OBJECTIVE: Orostachys japonicus A. Berger (Crassulaceae) has been used in traditional herbal medicines in Korea and other Asian countries to treat various diseases, including liver disorders. In the present study,... -
- CITED
-
- Close
- SHARE
-
- Close
