- A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon
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Choi SW, Tammen SA, Liu Z, Friso S
- KMID: 2313851
- Nutr Res Pract.
- 2015 Aug;9(4):358-363.
- doi: 10.4162/nrp.2015.9.4.358
BACKGROUND/OBJECTIVES: Previous studies have indicated that when compared to young mice, old mice have lower global DNA methylation and higher p16 promoter methylation in colonic mucosa, which is a common... -
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- Iron Supplementation Reverses the Reduction of Hydroxymethylcytosine in Hepatic DNA Associated With Chronic Alcohol Consumption in Rats
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Tammen SA, Park JE, Shin PK, Friso S, Chung J, Choi SW
- KMID: 2367564
- J Cancer Prev.
- 2016 Dec;21(4):264-270.
- doi: 10.15430/JCP.2016.21.4.264
BACKGROUND: Alcohol is known to affect two epigenetic phenomena, DNA methylation and DNA hydroxymethylation, and iron is a cofactor of ten-eleven translocation (TET) enzymes that catalyze the conversion from methylcytosine... -
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- Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
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Yoon A, Tammen SA, Park S, Han SN, Choi SW
- KMID: 2412022
- Nutr Res Pract.
- 2017 Apr;11(2):105-113.
- doi: 10.4162/nrp.2017.11.2.105
BACKGROUND/OBJECTIVES: A high-fat diet (HFD) induces obesity, which is a major risk factor for cardiovascular disease and cancer, while a calorie-restricted diet can extend life span by reducing the risk... -
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