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Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis

Zhang L, Yu M, Deng J, Lv X, Liu J, Xiao Y, Yang W, Zhang Y, Li C

PURPOSE: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Chemokines are involved in RA pathogenesis. In this study,...
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Molecular MR Imaging for Visualizing ICAM-1 Expression in the Inflamed Synovium of Collagen-Induced Arthritic Mice

Lee SI, Lee SY, Yoon KH, Choi KS, Jang KY, Yoo WH, Kim SH, Choi TH, Park JG

OBJECTIVE: To determine the utility of intercellular adhesion molecule (ICAM)-1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA-anti-ICAM-1) as a targeted contrast agent for the molecular magnetic resonance imaging (MRI) in collagen-induced arthritis...
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