- The inhibitory effect of opioid on the hyperpolarization-activated cation currents in rat substantia gelatinosa neurons
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Seol GH, Kim J, Cho SH, Kim WK, Kim JW, Kim SJ
- KMID: 1607076
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):373-380.
The action of opioid on the hyperpolarization-activated cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents... -
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- Peripheral Nerve Injury Alters Excitatory and Inhibitory Synaptic Transmission in Rat Spinal Cord Substantia Gelatinosa
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Youn DH
- KMID: 1600055
- Korean J Physiol Pharmacol.
- 2005 Jun;9(3):143-147.
Following peripheral nerve injury, excessive nociceptive inputs result in diverse physiological alterations in the spinal cord substantia gelatinosa (SG), lamina II of the dorsal horn. Here, I report the alterations... -
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- Ryanodine Receptor-mediated Calcium Release Regulates Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
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Park A, Chun SW
- KMID: 2133226
- Int J Oral Biol.
- 2015 Dec;40(4):211-216.
- doi: 10.11620/IJOB.2015.40.4.211
Nitric Oxide (NO) is an important signaling molecule in the nociceptive process. Our previous study suggested that high concentrations of sodium nitroprusside (SNP), a NO donor, induce a membrane hyperpolarization... -
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- Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice
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Park SA, Park SJ, Han SK
- KMID: 1072178
- J Vet Sci.
- 2010 Dec;11(4):299-304.
- doi: 10.4142/jvs.2010.11.4.299
The KA1 kainate receptor (KAR) subunit in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) has been implicated in the processing of nociceptive information from the orofacial region.... -
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- Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice
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Nguyen HT, Cho DH, Jang SH, Han SK, Park SJ
- KMID: 2450494
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):271-279.
- doi: 10.4196/kjpp.2019.23.4.271
The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and... -
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- Epidural Morphine Block for Chronic Pain
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Choi CR, Kim Y, Hwang JH, Ahn MS
- KMID: 2187348
- J Korean Neurosurg Soc.
- 1983 Sep;12(3):369-374.
Epidural injection of 2-4mg morphine for 7-14 days were given to 18 patients with severe chronic pain. All cases except 2 arachnoiditis had considerable amelioration of pain, which commenced within... -
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- Mechanism of Glutamate-induced[Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats
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Jung SJ, Choi JS, Kwak J, Kim J, Kim JW, Kim SJ
- KMID: 2285271
- Korean J Physiol Pharmacol.
- 2003 Apr;7(2):53-58.
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellularCa (2+) concentration ([Ca2+]i) and induces... -
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- Pre- and Postsynaptic Actions of Reactive Oxygen Species and Nitrogen Species in Spinal Substantia Gelatinosa Neurons
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Park A, Chun SW
- KMID: 2437338
- Int J Oral Biol.
- 2018 Dec;43(4):209-216.
- doi: 10.11620/IJOB.2018.43.4.209
Reactive oxygen species (ROS) and nitrogen species (RNS) are involved in cellular signaling processes as a cause of oxidative stress. According to recent studies, ROS and RNS are important signaling... -
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- Epilural Morphine in Treatment of Caneer Pain
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Kim MS, Yoon JS, Kim MY, Kim KS, Kim HD, Kim YS, Park DH, Kim WS
- KMID: 2357490
- Korean J Anesthesiol.
- 1980 Jun;13(2):135-139.
Epidural injection of 2.0 mg morphine with distilled water or 0.9 % normal saline 10 ml were given to a bladder cancer patient with severe chronic intraetable pain which... -
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- Involvement of Crosstalk Between cAMP and cGMP in Synaptic Plasticity in the Substantia Gelatinosa Neurons
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Kim TH, Chung G, Park SB, Chey WY, Jung SJ, Kim JS, Oh SB
- KMID: 2170737
- Int J Oral Biol.
- 2011 Jun;36(2):83-89.
Substantia gelatinosa (SG) neurons receive synaptic inputs from primary afferent Adelta- and C-fibers, where nociceptive information is integrated and modulated by numerous neurotransmitters or neuromodulators. A number of studies were... -
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- Effects of Reactive Oxygen Species and Nitrogen Species on the Excitability of Spinal Substantia Gelatinosa Neurons
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Park JY, Park A, Chun SW
- KMID: 2354202
- Int J Oral Biol.
- 2016 Sep;41(3):141-147.
- doi: 10.11620/IJOB.2016.41.3.141
Reactive oxygen species (ROS) and nitrogen species (RNS) are both important signaling molecules involved in pain transmission in the dorsal horn of the spinal cord. Xanthine oxidase (XO) is a... -
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- Effect of Epidural Morphine on Postoperative Pain and Arterial Blood Gas Values
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Woo NS, Lee HJ, Oh HK
- KMID: 2357489
- Korean J Anesthesiol.
- 1980 Jun;13(2):128-134.
After the identification by Snyder of specific opiate receptors it the substantia gelatinosa of the posterior horn of the spinal cord, Behar et al. reported that small doses of epidural... -
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- Botulinum toxin type A enhances the inhibitory spontaneous postsynaptic currents on the substantia gelatinosa neurons of the subnucleus caudalis in immature mice
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Jang SH, Park SJ, Lee CJ, Ahn DK, Han SK
- KMID: 2419003
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):539-546.
- doi: 10.4196/kjpp.2018.22.5.539
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus... -
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- Effects of NaOCl on Neuronal Excitability and Intracellular Calcium Concentration in Rat Spinal Substantia Gelatinosa Neurons
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Lee HI, Park AR, Chun SW
- KMID: 1431123
- Int J Oral Biol.
- 2013 Mar;38(1):5-12.
Recent studies indicate that reactive oxygen species (ROS) can act as modulators of neuronal activity, and are critically involved in persistent pain primarily through spinal mechanisms. In this study, we... -
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- Glycine- and GABA-mimetic Actions of Shilajit on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Mice
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Yin H, Yang EJ, Park SJ, Han SK
- KMID: 2071731
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):285-289.
- doi: 10.4196/kjpp.2011.15.5.285
Shilajit, a medicine herb commonly used in Ayurveda, has been reported to contain at least 85 minerals in ionic form that act on a variety of chemical, biological, and physical... -
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- Caudal Morphine for Postoperative Pain Control after Abdominal Surgery
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Woo NS, Yoon DM, Oh HK
- KMID: 2237199
- Korean J Anesthesiol.
- 1981 Sep;14(3):283-288.
Caudal narcotic analgesia was assessed after the injection of 3mg morphine diluted in 30ml(physiologic) saline into the sacral canal in 15 patients after upper abdominal surgery, in 20 patients... -
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- Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords
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Uta D, Hattori T, Yoshimura
- KMID: 2446742
- Int Neurourol J.
- 2019 Mar;23(1):13-21.
- doi: 10.5213/inj.1938056.028
PURPOSE: The aim of this study was to characterize the responsiveness of miniature excitatory postsynaptic currents (mEPSCs) to α1-adrenoceptor blockers in substantia gelatinosa (SG) neurons from the spinal cord to... -
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- Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro
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Uta D, Hattori T, Yoshimura
- KMID: 2431866
- Int Neurourol J.
- 2018 Dec;22(4):252-259.
- doi: 10.5213/inj.1836146.073
PURPOSE: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil... -
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- DAMGO modulates two-pore domain K⺠channels in the substantia gelatinosa neurons of rat spinal cord
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Cho PS, Lee HK, Lee SH, Im JZ, Jung SJ
- KMID: 2350509
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):525-531.
- doi: 10.4196/kjpp.2016.20.5.525
The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying Kâº... -
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- Reactive Oxygen Species and Nitrogen Species Differentially Regulate Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
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Lee HI, Park AR, Chun SW
- KMID: 2170792
- Int J Oral Biol.
- 2014 Dec;39(4):229-236.
- doi: 10.11620/IJOB.2014.39.4.229
Reactive oxygen species (ROS) and nitrogen species (RNS) are implicated in cellular signaling processes and as a cause of oxidative stress. Recent studies indicate that ROS and RNS are important... -
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