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The mechanism of c-erbB-2 gene product increase in stomach cancer cell lines

Bae CD, Park SE, Seong YS, Kim SW, park JB, Park JG

c-erbB-2 oncogene encodes a growth factor receptor whose amino acid sequence has extensive homology with human epidermal growth factor receptor. It is frequently overexpressed in human breast, ovary, lung, and...
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Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells

Bae CD, Juhnn YS, Park JB

  • KMID: 755111
  • Exp Mol Med.
  • 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the...
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Prognostic Significance of p21 and p53 Expression in Gastric Cancer

Seo YH, Joo YE, Choi SK, Rew JS, Park CS, Kim SJ

  • KMID: 1106143
  • Korean J Intern Med.
  • 2003 Jun;18(2):98-103.
BACKGROUND: Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of...
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Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma

Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES

BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such...
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Continuous hypoxia attenuates paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line

Kim H, Lee SW, Baek KM, Park JS, Min JH

Paraquat (1,1'-dimethyl-4,4'-bipyridinium dichloride; PQ), an effective and widely used herbicide, was commercially introduced in 1962. It is reduced by the electron donor NADPH, and then reduced PQ transfers the electrons...
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