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Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells

Kang DW, Min G, Park DY, Hong KW, Min DS

Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed...
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Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells

Mutoh H, Sashikawa , Sakamoto H, Tateno T

BACKGROUND/AIMS: Doublecortin and CaM kinase-like-1 (DCAMKL1) is a marker of stem cells expressed predominantly in the crypt base in the intestine. However, DCAMKL1-positive cells have been shown to be differentiated...
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Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas

Jang TJ, Ji YS, Jung KH

PURPOSE: Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often...
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