- Sterculic Acid and Its Analogues Are Potent Inhibitors of Toxoplasma gondii
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Hao P, Alaraj IQ, Al Dulayymi JR, Baird MS, Liu J, Liu Q
- KMID: 2164010
- Korean J Parasitol.
- 2016 Apr;54(2):139-145.
- doi: 10.3347/kjp.2016.54.2.139
Toxoplasmosis is a serious disease caused by Toxoplasma gondii, one of the most widespread parasites in the world. Lipid metabolism is important in the intracellular stage of T. gondii. Stearoyl-CoA... -
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- Carnosic Acid Inhibits Lipid Accumulation in 3T3-L1 Adipocytes Through Attenuation of Fatty Acid Desaturation
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Park MY, Sung MK
- KMID: 2171316
- J Cancer Prev.
- 2015 Mar;20(1):41-49.
- doi: 10.15430/JCP.2015.20.1.41
BACKGROUND: Excess body fat accumulation contributes to the development of metabolic disorders that can cause adverse health effects. Carnosic acid (CA), a major bioactive component of rosemary (Rosemarinus officinalis), has... -
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- Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis
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Dhami-Shah H, Vaidya R, Udipi S, Raghavan S, Abhijit S, Mohan V, Balasubramanyam M, Vaidya A
- KMID: 2429085
- Clin Mol Hepatol.
- 2018 Mar;24(1):77-87.
- doi: 10.3350/cmh.2017.0039
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could... -
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- Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition
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Mohammadzadeh F, Mosayebi G, Montazeri , Darabi M, Fayezi S, Shaaker M, Rahmati M, Baradaran , Mehdizadeh A, Darabi M
- KMID: 2353068
- J Breast Cancer.
- 2014 Jun;17(2):136-142.
PURPOSE: Stearoyl-CoA desaturase 1 (SCD1) is a novel therapeutic target in various malignancies, including breast cancer. The present study was designed to investigate the effect of the pharmacologic inhibition of... -
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- Dietary carnosic acid suppresses hepatic steatosis formation via regulation of hepatic fatty acid metabolism in high-fat diet-fed mice
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Park MY, Mun ST
- KMID: 2313683
- Nutr Res Pract.
- 2013 Aug;7(4):294-301.
In this study, we examined the hepatic anti-steatosis activity of carnosic acid (CA), a phenolic compound of rosemary (Rosmarinus officinalis) leaves, as well as its possible mechanism of action, in... -
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- Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model
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Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM
- KMID: 2456220
- Biomol Ther.
- 2019 Sep;27(5):457-465.
- doi: 10.4062/biomolther.2018.214
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in... -
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