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Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Jeon GW, Sheldon RA, Ferriero D

BACKGROUND: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does...
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A Patient Diagnosed with Spinocerebellar Ataxia Type 5 associated with SPTBN2: Case Report

Hur MW, Ko A, Lee HJ, Lee JS, Kang HC

Spinocerebellar ataxias (SCAs) are autosomal dominant neurodegenerative disorders which disrupt the afferent and efferent pathways of the cerebellum that cause cerebellar ataxia. Spectrin beta non-erythrocytic 2 (SPTBN2) gene encodes the...
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Spectrin Tunis (Sp alpha I/78) in a Korean Family with Hereditary Elliptocytosis

Han E, Kim A, Park J, Kim M, Kim Y, Han K, Kim YJ

No abstract available.
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Hereditary Spherocytosis

Park ES

  • KMID: 2049272
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):57-63.
Hereditary spherocytosis is a hemolytic anemia caused by erythrocyte membrane deficiencies that lead to membrane destabilization and vesiculation. Abnormal spherocytes are trapped and destroyed in the spleen. Mutations in several...
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Spectrin Cleavage Induced by LLP-1 Lentivirus Lytic Peptide Domain in the Intracytoplasmic Tail of Human Immunodeficiency Virus Type 1 GP41 in Rat Organotypic Hippocampal Slice Cultures

Lee JH, Lee EO, Chong YH

We previously demonstrated that the lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induced cell death in human neuronal cells. Present study was conducted to...
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Kinesin Superfamily KIF5 Proteins Bind to betaIII Spectrin

Paik JE, Kim N, Yea SS, Jang WH, Chung JY, Lee SK, Park YH, Han J, Seog DH

  • KMID: 2285302
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):167-172.
The kinesin proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF5 is a heterotetrameric motor that conveys vesicles...
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Associations between Lead Exposure and Dose and Protein Kinase C Activation in Erythrocytes Among Lead Workers

Hwang KY, Hwangbo Y, Ahn HC, Kim YB, Lee GS, Lee SS, Ahn KD, Lee BK

  • KMID: 2028161
  • Korean J Occup Environ Med.
  • 2001 Dec;13(4):369-375.
OBJECTIVES: Protein kinase C(PKC), a calcium and phospholipid dependent enzyme, is activated by lead in vitro at picomolar concentrations. However, the effect of lead on PKC has never been studied...
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Abnormalities of erythrocyte membrane proteins in Korean patients with hereditary spherocytosis

Lee YK, Cho HI, Park SS, Lee YJ, Ra E, Chang YH, Hur M, Shin HY, Ahn HS

Hereditary spherocytosis (HS) is a common inherited erythrocyte membrane disorder characterized by chronic hemolytic anemia. Clinical manifestations and biochemical abnormalities of HS are heterogeneous. In this study, we investigated erythrocyte...
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SDS-PAGE Analysis of Red Cell Membrane Proteins in Hereditary Hemolytic Anemia

Lee YK, Cho HI, Park SS, Ra E, Chang YH, Hur M, Lee YJ, Shin HY, Ahn HS

  • KMID: 1533972
  • Korean J Hematol.
  • 1999 Nov;34(4):559-567.
BACKGROUND: Red cell membrane is a lipid bilayer laminated by the membrane cytoskeleton at the surface of inner monolayer. A class of hemolytic anemia, such as hereditary spherocytosis (HS) or...
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Erythrocyte Membrane Protein Alterations by SDS-PAGE and Underlying Clinical Heterogeneity in Hereditary Spherocytosis

Yoo ES, Choi HS, Shin HY, Ahn HS, Lee YK, Cho HI

  • KMID: 1979968
  • Korean J Pediatr Hematol Oncol.
  • 1997 Oct;4(2):261-272.
BACKGROUND: Hereditary spherocytosis(HS) is a clinically and biochemically very heterogeneous disorder The purpose of this study is to detect erythrocyte membrane protein abnormalities by SDS-PAGE and to investigate the frequency...
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Splenectomy in Hereditary Spherocytosis in Childhood

Heo YS, Kim CS, Do BS, Suh BY, Hah JO

Among the erythrocyte membrane defects, hereditary spherocytosis is the most common. The erythrocyte membrane defect results from a deficiency of spectrin, the most important structural protein in red cell. Hereditary spherocytosis...
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Purification of Band 3 from the Human Erythrocyte Membrane and its Incorporation into Liposome

Kim JR, Kim JH, Lee KY

Band 3, the predominant 95,000 dalton anion transport protein, is the major intrinsic glycoprotein of the human erythrocyte membrane. This anion carrier exists as a dimer and binds the cytoskeletons...
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