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The Effect of the Vitamin Protocol for Treating Sepsis or Septic Shock in Pediatric Intensive Care Unit

Ko HJ, Jung MJ, Kim JS, Son ES, Yu YM

Background: Recently, a study comprising adult patients with sepsis admitted in the intensive care unit (ICU) was conducted. The patients were treated with high doses of intravenous ascorbic acid, thiamine,...
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Medication Utilization Analysis of Basiliximab as a Maintenance Immunosuppressant in Renal Failure Patients Undergoing Lung Transplantation

Seo Y, Geum MJ, Lee KA, Kim JS, Son ES, Yu YM

Background: Basiliximab is used as an alternative to tacrolimus in patients with decreased renal function. However, studies on basiliximab as a maintenance immunosuppressant, particularly in patients with lung transplantation, are...
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Efficacy and Safety of Antipsychotics for Delirium Treatment in Cancer Patients Receiving Palliative Care

Oh S, Geum MJ, Kim JS, Son ES, Yu YM

Background: Delirium is a neuropsychiatric disorder characterized by sudden impairments in consciousness, attention, and perception. The evidence of successful pharmacological interventions for delirium is limited, and medication recommendations for managing...
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Associations of COL2A1 Gene Polymorphisms and Ankylosing Spondylitis in the Korean Population

Son ES, Um SH, Youn MY

With highly active antiretroviral therapy, human immunodeficiency virus (HIV) infection is considered to be a manageable chronic disease. The improved prognosis increases the desire of individuals with HIV to have...
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Delayed Elimination After High-dose Methotrexate in Pediatric Patients with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma

Yoon HW, Ree YS, Song HS, Kim JS, Son ES

BACKGROUND: High doses of methotrexate (MTX) are often used in various chemotherapy protocols to treat acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) in children, but its delayed elimination increases...
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Validation of Voriconazole Therapeutic Drug Monitoring in Lung Transplant Recipients Receiving Voriconazole alone for Treatment of Invasive Aspergillosis

Son YJ, Lee KA, Jo JH, Kim JS, Son ES, Park MS

BACKGROUND: Invasive aspergillosis (IA) is associated with high morbidity and mortality, particularly among immunocompromised patients, such as lung transplant recipients. Voriconazole, the first-line therapy for IA, shows a non-linear pharmacokinetic...
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Incidence and Associated Factors of Delirium after Orthopedic Surgery

Lee SW, Cho CH, Bae KC, Lee KJ, Son ES, Um SH

PURPOSE: To investigate the incidence and associated factors of delirium after orthopedic surgery. MATERIALS AND METHODS: A total of 2,122 cases, who were older than 20 years and underwent orthopedic surgery...
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Analysis of Compliance and Clinical Outcomes by Expanding Physician's Departments in Pediatric Nutrition Support Team

Lee HW, Jung MJ, Park JE, Kwon H, Kim JS, Go H, Son ES

PURPOSE: Malnutrition in hospitalized children has an impact on growth, morbidity, and mortality. For this reason, the implementation of pediatric nutrition support team (PNST) has been suggested. On April 2017,...
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Posaconazole for Prophylaxis of Fungal Infection in Pediatric Patients with Acute Myeloid Leukemia undergoing Induction Chemotherapy

Kim SM, Ree YS, Kim JS, Kim SH, Son ES, Lyu CJ

BACKGROUND: Posaconazole is a broad-spectrum triazole antifungal agent and the most recommended prophylactic antifungal agent for patients with acute myeloid leukemia (AML) undergoing induction chemotherapy. In this study, we evaluated...
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Comparison of Piperacillin/Tazobactam Dosing (13.5 g/day vs. 18 g/day) for the Treatment of Hospital-Acquired Pneumonia and Ventilator-associated Pneumonia in Intensive Care Unit

Kang JY, Lee KA, Kim JS, Kim SH, Son ES

BACKGROUND: In July 2016, the Infectious diseases society of america and the american thoracic society (IDSA & ATS) published a guideline recommending piperacillin/tazobactam (Pip/Tazo) 18 g/day as the anti-pseudomonal dose...
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Osteochondroma of the Distal Clavicle: A Rare Cause of Impingement and Biceps Tear of the Shoulder

Kim DW, Bae KC, Son ES, Baek CS, Cho CH

Hereditary multiple exostosis (HME) is an autosomal dominant disorder manifested by the presence of multiple osteochondromas. Although the lesions are benign in nature, exostoses are often associated with characteristic progressive...
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Effects of Parenteral Nutrition in Pediatric Patients with Hematopoietic Stem Cell Transplantation

Lim SY, Jung MJ, Park JE, Kim JS, Kim SH, Lyu CJ, Son ES

PURPOSE: This study examined the effects of parenteral nutrition (PN) on the nutritional status, clinical improvement, and PN-related complications in pediatric patients who had undergone hematopoietic stem cell transplantation (HSCT). METHODS:...
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The Development of Multidisciplinary Cancer Patient Education·Counseling Questionnaire and Satisfaction Survey

Lee MJ, Geum MJ, Kim JS, Kim SH, Son ES, Lee SG, Song SK, Choi HJ

BACKGROUND: Presently, a multidisciplinary team of doctors, pharmacists, nurses, and dietitians provides patient education to impart information on chemotherapy. However, studies on multidisciplinary education satisfaction are inadequate. In this study,...
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The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells

Kyung SY, Kim YJ, Son ES, Jeong SH, Park JW

BACKGROUND: Recent studies show that mitophagy, the autophagy-dependent turnover of mitochondria, mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure and contributes to the development of...
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Clinical Features of Serious Adverse Drug Reactions in a Tertiary Care Hospital in Korea

Seo Y, Han Y, Kim SH, Son ES, Sim DW, Park KH, Park JW

BACKGROUND/AIMS: Several studies have reported on the clinical aspects of adverse drug reactions (ADRs). To date, no study has evaluated serious adverse drug reactions (SADRs) in Korea. The current study...
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Changes in Renal Function by Nebulized Colistimethate Treatment

Ahn HJ, Jung YJ, Kim JS, Kim SH, Son ES

BACKGROUND: Nebulized colistimethate is increasingly used, because there are problems such as renal dysfunction and low distribution within the lungs when colistimethate is administered intravenously. This study was designed to...
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A Comparison of Vancomycin and Metronidazole for the Treatment of Clostridium difficile-associated Diarrhea (CDAD) in Medical Intensive Care Unit (MICU)

Cho EA, Lee KA, Kim JS, Kim SH, Son ES

BACKGROUND: Clostridium difficile associated diarrhea (CDAD) is a leading cause of hospital-associated gastrointestinal illness. Risk factors for CDAD include advanced age, long-term admission, antibiotics, proton-pump inhibitor or Hâ‚‚ blocker use...
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Influence of Fish Oil-Containing Lipid Emulsions on Parenteral Nutrition-Associated Liver Disease in Neonates

Park JA, Park JE, Jeong MJ, Kim JS, Son ES, Eun HS

PURPOSE: This study is a comparative evaluation of the incidence of parenteral nutrition-associated liver disease (PNALD) when administering intravenous fat emulsions containing fish oil. METHODS: The medical records of patients who...
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Dapagliflozin's Effects on Glycemia and Cardiovascular Risk Factors and Incidence of Adverse Events in Patients with Type 2 Diabetes

Lee HJ, Geum MJ, Kim JS, Kim K, Son ES

BACKGROUND: Dapagliflozin is an oral selective inhibitor of sodium-glucose cotransporter 2(SGLT2), the kidney transporter chiefly responsible for glucose reabsorption from the glomerular filtrate. Because this mechanism does not require the...
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Effects of Compliance with the Nutrition Support Team in Critically Ill Pediatric Patients

Park SJ, Park JE, Kwon NY, Kim JS, Son ES, Yu HJ, Bang JY, Kim S, Eun HS

PURPOSE: This study performed a comparative evaluation of nutritional condition's improvement and clinical effects in accordance with the Nutrition Support Team (NST) consultation compliance of critically ill pediatric patients. METHODS: The...
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