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SUMO Proteins are not Involved in TGF-beta1-induced, Smad3/4-mediated Germline alpha Transcription, but PIASy Suppresses it in CH12F3-2A B Cells

Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR

TGF-beta induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-beta signal-transducing transcription factors, mediate germline (GL) alpha transcription induced by TGF-beta1, resulting in...
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Molecules and their functions in autophagy

Pyo JO, Nah J, Jung YK

Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved...
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PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ

  • KMID: 756067
  • Exp Mol Med.
  • 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain...
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