- Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome
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Kang YM, Lee HM, Moon SH, Kang H, Choi YR
- KMID: 2427132
- Yonsei Med J.
- 2017 Mar;58(2):415-422.
- doi: 10.3349/ymj.2017.58.2.415
PURPOSE: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforming growth factor beta (TGF-β). MATERIALS AND METHODS: To test the anti-fibrotic... -
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- miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell Differentiation by Downregulating Syndecan4
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Kee HJ, Kim GR, Cho SN, Kwon JS, Ahn Y, Kook H, Jeong MH
- KMID: 2223887
- Korean Circ J.
- 2014 Jul;44(4):255-263.
- doi: 10.4070/kcj.2014.44.4.255
BACKGROUND AND OBJECTIVES: Differentiation and de-differentiation of vascular smooth muscle cells (VSMCs) are important events in atherosclerosis and restenosis after angioplasty. MicroRNAs are considered a key regulator in cellular processes... -
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- PPARgamma Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
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Han JY, Kim YJ, Kim L, Choi SJ, Park IS, Kim JM, Chu YC, Cha DR
- KMID: 1713829
- J Korean Med Sci.
- 2010 Jan;25(1):35-41.
- doi: 10.3346/jkms.2010.25.1.35
The peroxisome proliferator activated receptor (PPAR)gamma agonist is used as antidiabetic agent with antihyperglycemic and antihyperinsulinemic actions. Beyond these actions, antifibrotic effects have been reported. We examined antifibrotic effects of... -
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- Synovial fluid of patients with rheumatoid arthritis induces alpha-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-beta1-dependent mechanism
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Song HY, Kim MY, Kim KH, Lee IH, Shin SH, Lee JS, Kim JH
- KMID: 1104383
- Exp Mol Med.
- 2010 Aug;42(8):565-573.
- doi: 10.3858/emm.2010.42.8.057
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Transforming growth factor-beta1 (TGF-beta1) is a secreted protein that promotes differentiation of... -
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- Parathyroid hormone accelerates decompensation following left ventricular hypertrophy
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Cha H, Jeong HJ, Jang SP, Kim JY, Yang DK, Oh JG, Park WJ
- KMID: 946670
- Exp Mol Med.
- 2010 Jan;42(1):61-68.
- doi: 10.3858/emm.2010.42.1.006
Parathyroid hormone (PTH) treatment was previously shown to improve cardiac function after myocardial infarction by enhancing neovascularization and cell survival. In this study, pressure overload-induced left ventricular hypertrophy (LVH) was... -
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- TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions
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Nam EH, Park SR, Kim PH
- KMID: 983953
- Exp Mol Med.
- 2010 Sep;42(9):606-613.
- doi: 10.3858/emm.2010.42.9.059
Angiogenesis is a multi-step process that involves the activation, proliferation, and migration of endothelial cells. We have recently shown that TGF-beta1 can induce mouse macrophages to produce VEGF, a potent... -
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