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In Vivo Study for Percutaneous Absorption of Topical Corticosteroids using The Peel-Off Type Pack as a Vehicle

Cho JH, Jue SJ, Ro YS

  • KMID: 2086710
  • Korean J Dermatol.
  • 2003 Sep;41(9):1169-1176.
BACKGROUND: Packs are viscous preparations that produce a film over the skin surface, thus preventing the evaporation of water and increasing the skin temperature. Because of this occlusive effect, packs...
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measurement of Percutaneous Absorption Using Fluorescence Polarization Immunoassays in a Diffusion Chamber

Lee WJ, Kim YH, Kim DW, Jun JB, Chung SL

  • KMID: 1891501
  • Korean J Dermatol.
  • 1996 Oct;34(5):718-724.
BACKGROUND: The penetraton in vivo of topically applied substances can be assessed by physiological or pharmacalogical signs or analysed by chemical or histological techniques. In vitro absorption can be commonly...
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Ultrasonic Device Part II: The Adverse Effects of Ultrasonic Device for Medical Skin Care

Lee MW, Lee GJ, Ryu HJ, Ko JY

  • KMID: 1427464
  • Korean J Dermatol.
  • 2013 May;51(5):311-314.
An ultrasonic device for medical skin care is used to gently exfoliate the skin of dead skin cells and impurities. Ultrasound waves help loosen and remove oil, dirt and cellular...
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Permeation Pharmacokinetics of Hyperosmolar Glucose Through Stratum Corneum

Kim SJ, Lee DS, Choi HK, Lee SC, Won YH

  • KMID: 2302762
  • Korean J Dermatol.
  • 2004 Nov;42(11):1425-1430.
BACKGROUND: The role of stratum corneum has been known to be the major barrier against percutaneous absorption. The change of osmotic gradient onto stratum corneum may affect the permeability barrier...
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Dermatological Applications of Iontophoresis

Lee SH, Choi CP, Kim J

  • KMID: 2388390
  • Korean J Dermatol.
  • 2013 Jun;51(6):409-414.
Transdermal drug delivery is applicable to only a few drugs because the stratum corneum is an excellent barrier to percutaneous absorption. Iontophoresis is a non-invasive technique which increases the drug...
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Dermal Exposure Associated with Occupational End Use of Pesticides and the Role of Protective Measures

MacFarlane E, Carey R, Keegel T, El-Zaemay , Fritschi L

  • KMID: 2317095
  • Saf Health Work.
  • 2013 Sep;4(3):136-141.
BACKGROUND: Occupational end users of pesticides may experience bodily absorption of the pesticide products they use, risking possible health effects. The purpose of this paper is to provide a guide...
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Influence of Ultrasound on the Percutaneous Absorption of Methyl Nicotinate

Hwang SJ, Chung SL, Kim DW, Jun JB

  • KMID: 2116007
  • Korean J Dermatol.
  • 1997 Oct;35(5):947-955.
BACKGROUND: The mechanism of enhancing effect of ultrasound on the percutaneous absorption of a drug is unclear. But thermal, chemical and mechanical effects are assumed to play a role in...
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Treatment of Side Effects Caused by Electrically Powered Medical Skin Care Equipment

Jung KE, Park JS, Hong SP, Kim MH, Park BC

  • KMID: 2246399
  • Korean J Dermatol.
  • 2014 Feb;52(2):77-81.
Radio frequency and iontophoresis are two commonly used types of medical skin care equipment, utilizing electrical energy. Radio frequency technology has become an important treatment in aesthetic medicine, and has...
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The measurement of serum corticosteroid level in atopic dermatitis patients associated with application of topical corticosteroids

Kang HG, Lee SA, Kim HJ, Yum HY

PURPOSE: Most of the atopic dermatitis (AD) patients and their parents refuse topical treatment because of concern about generalized side effect due to systemic absorption of topical corticosteroids. Therefore, a...
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The Rate of Recovery after Disruption of the Skin Barrier and the composition of Human Surface Lipids at Different Anatomic Sites of Skin

Lee SH, Koo SW, Hwang MS, Lee WJ, Kim DW

  • KMID: 2230706
  • Korean J Dermatol.
  • 1996 Feb;34(1):38-45.
BACKGROUND: Lipids in the stratum corneum which acts as a barrier prevents transepidermal water loss and percutaneous absorption of a substance differs at different anatomic sites of skin. No study...
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The Ultrastructural Changes of Stratum Corneum Lipids after Application of Oleic Acid in Propylene Glycol

Jiang SJ, Kim YK, Lee SH

BACKGROUND: The stratum corneum presents a significant barrier to transdermal drug delivery. Approaches to improve percutaneous absorption of drugs have included iontophoresis and skin penetration enhancers. Oleic acid has been...
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Skin Barrier Function Evaluated by Transepidermal Water Loss and Vascular Response to Percutaneous Absorption of Methyl Nicotinate

Lee JW, Jun JB, Kim DW, Chung SL

  • KMID: 2425602
  • Korean J Dermatol.
  • 1997 Dec;35(6):1121-1129.
BACKGROUND: The measurement of transepidermal water loss(TEWL) is widely used in evaluating the stratum corneum barrier function. It is also possible to evaluate the penetration of substances into the skin...
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Water-Impermeable Occlusion Effect to Intercorneocyte Lipid Layers in Hairless Mice

Jiang S, Youl S, Lee SH

BACKGROUND: Stratum corneum lipids are arranged as intercellular membrane bilayers presumed to mediate the epidermal permeability barrier. Acute disruption in barrier function will initiate epidermal lipid synthesis, which can be...
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Vitamin C-iontophoresis in Melasma

Yoo JM, Park HJ, Choi SW, Kim HO

  • KMID: 1595016
  • Korean J Dermatol.
  • 2001 Mar;39(3):285-291.
BACKGROUND: An inhibitory effect of ascorbic acid(AsA) on melanogenesis has been described. Iontophoresis is emerging technologies capable of enhancing drug penetration through stratum corneum, the principal barrier to percutaneous absorption. OBJECTIVE:...
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The Iontophoresis Effect on Recovery After Acute Epidemal Barrier Disruption

Lee SH, Jiang S, Park TH, Yoo CB, Choi EH, Ahn SK

  • KMID: 2303549
  • Korean J Dermatol.
  • 1996 Jun;34(3):375-380.
BACKGROUND: The stratum corneum(SC) has a permeability barrier function which regulates percutaneous absorption by the inhibition of transepidermal water loss(TEWL). Acute mechanical or chemical disruption of the SC induces the...
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Analysis of Influencing Factors on Female Hairdresser's Neuropsychiatric Symptoms Due to Chronic Organic Solvent Exposure

Kim SA, Kim EJ, Park WS, Jung SH

  • KMID: 2028172
  • Korean J Occup Environ Med.
  • 2002 Mar;14(1):13-22.
OBJECTIVES: This study was designed to examine the influencing factors on female hairdresser's neuropsychiatric symptoms due to chronic organic solvent exposure. METHODS: We collected data from 143 female hairdressers employed in...
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Toxic Hepatitis Induced by Occupational Dimethylacetamide Exposure

Choi TS, Woo KH, Kim JS, Park WS, Ham JH, Jung SJ, Yu JY

  • KMID: 2074990
  • Korean J Occup Environ Med.
  • 2001 Jun;13(2):164-170.
Dimethylacetamide is widely used in the production of plastics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid...
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Polyneuropathy by Occupational Exposure to Acrylamide

Cheong HK, Kwon YW, Uh KY, Kim BJ, Yang JS, Jung C, Jin Y, Lee MY, Kang SK

  • KMID: 2074968
  • Korean J Occup Environ Med.
  • 1998 Aug;10(3):388-403.
Authors report a first Korean case of polyneuropathy in an acrylamide producing factory together with an environmental and epidemiologic survey for the ten workers of the same workplace and 46...
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Changes of Antimicrobial Peptides and Transepidermal Water Loss After Topical Application of Tacrolimus and Ceramide-dominant Emollient in Patients with Atopic Dermatitis

Park KY, Kim DH, Jeong MS, Li K, Seo SJ

Increased transepidermal water loss (TEWL) and downregulated antimicrobial peptides (AMPs) are observed in patients with atopic dermatitis (AD). Tacrolimus and ceramide-dominant emollients are effective in the treatment of AD by...
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A Case of Exfoliative Dermatitis with Renal and Bone Marrow Failires due to Topical Metalic Mercury

Kim BH, Hong HP, Kim BK, Kim CW, Houh W

  • KMID: 1678218
  • Korean J Dermatol.
  • 1981 Apr;19(2):207-213.
Mercury had been an important constituent of the remedial drugs for last few centuries, but substantially replaced by more specific and effective mordern medicines. However, metalic mercury, tbe vestige of...
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