- Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
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Laks DR, Visnyei K, Kornblum H
- KMID: 1071412
- Yonsei Med J.
- 2010 Sep;51(5):633-640.
- doi: 10.3349/ymj.2010.51.5.633
At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem... -
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- Expression of MicroRNA in Host Cells Infected with Helicobacter pylori
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Chung JW, Jeong SH, Lee SM, Pak JH, Lee GH, Jeong JY, Kim JH
- KMID: 2412213
- Gut Liver.
- 2017 May;11(3):392-400.
- doi: 10.5009/gnl16265
BACKGROUND/AIMS: MicroRNAs (miRNAs) regulate gene expression. We assess miRNA regulation by Helicobacter pylori infection and elucidate their role in H. pylori-infected gastric epithelial cells. METHODS: The relationship between miRNA expression and... -
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- PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase
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Lee Y, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS
- KMID: 1009968
- Exp Mol Med.
- 2011 May;43(5):291-297.
- doi: 10.3858/emm.2011.43.5.030
Pancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of... -
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- Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway
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Jee B, Jin K, Hahn JH, Song HG, Lee H
- KMID: 1088655
- Exp Mol Med.
- 2003 Feb;35(1):30-37.
To investigate the functional role of KAI1/CD82, a metastasis suppressor for human prostate cancer, in the regulation of homotypic cell adhesion, we transfected KAI1 cDNA into DU 145 human prostate... -
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- Jak1/Stat3 Is an Upstream Signaling of NF-kappaB Activation in Helicobacter pylori-Induced IL-8 Production in Gastric Epithelial AGS Cells
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Cha B, Lim JW, Kim H
- KMID: 2450365
- Yonsei Med J.
- 2015 May;56(3):862-866.
- doi: 10.3349/ymj.2015.56.3.862
Helicobacter pylori (H. pylori) induces the activation of nuclear factor-kB (NF-kappaB) and cytokine expression in gastric epithelial cells. The Janus kinase/signal transducers and activators of transcription (Jak/Stat) cascade is the... -
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- MicroRNAs in Human Embryonic and Cancer Stem Cells
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Navarro A, Monzo M
- KMID: 1071411
- Yonsei Med J.
- 2010 Sep;51(5):622-632.
- doi: 10.3349/ymj.2010.51.5.622
MicroRNAs (miRNAs) are small non-coding RNAs that regulate messenger RNAs at the post-transcriptional level. They play an important role in the control of cell physiological functions, and their alterations have... -
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- STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
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Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH
- KMID: 1104801
- Exp Mol Med.
- 2008 Oct;40(5):479-485.
- doi: 10.3858/emm.2008.40.5.479
Hypoxia-inducible factor 1alpha (HIF-1alpha) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1alpha is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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