- Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1
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Fukuhara S, Sako K, Noda K, Nagao K, Miura K, Mochizuki
- KMID: 1123460
- Exp Mol Med.
- 2009 Mar;41(3):133-139.
- doi: 10.3858/emm.2009.41.3.016
Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor tyrosine kinase. Ang1-Tie2 signal has been proposed to exhibit two opposite roles in the controlling blood vessels. One is vascular stabilization and... -
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- Frontier of Epilepsy Research - mTOR signaling pathway
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Cho CH
- KMID: 1009965
- Exp Mol Med.
- 2011 May;43(5):231-274.
- doi: 10.3858/emm.2011.43.5.032
Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability. Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades and feedback regulation... -
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- Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK
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Lew BL, Cho Y, Kim J, Sim WY, Kim NI
- KMID: 2157790
- J Korean Med Sci.
- 2006 Feb;21(1):95-99.
- doi: 10.3346/jkms.2006.21.1.95
Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they... -
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- betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavbeta5 integrin
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Lee BH, Bae JS, Park RW, Kim JE, Park JY, Kim IS
- KMID: 1111408
- Exp Mol Med.
- 2006 Apr;38(2):153-161.
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes involve the interaction of VSMCs with extracellular matrix proteins. Here,... -
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- Butyrate regulates leptin expression through different signaling pathways in adipocytes
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Soliman MM, Ahmed MM, Salah-eldin AE, Abdel-Aal
- KMID: 1365014
- J Vet Sci.
- 2011 Dec;12(4):319-323.
- doi: 10.4142/jvs.2011.12.4.319
Leptin is an adipocytokine that regulates body weight, and maintains energy homeostasis by promoting reduced food intake and increasing energy expenditure. Leptin expression and secretion is regulated by various factors... -
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- Norcantharidin Induces Human Melanoma A375-S2 Cell Apoptosis through Mitochondrial and Caspase Pathways
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An WW, Wang MW, Tashiro SI, Onodera S, Ikejima T
- KMID: 2157686
- J Korean Med Sci.
- 2004 Aug;19(4):560-566.
- doi: 10.3346/jkms.2004.19.4.560
Norcantharidin (NCTD) is the demethylated form of cantharidin, which is the active substance of mylabris. To examine the pathway of NCTD-induced A375-S2 cell death, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide (MTT) assay,... -
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