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Pharmacotherapy of irritable bowel syndrome

Park CH, Han DS

Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly...
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New Generation Laxatives

Hong SN, Shin JE, Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Kim SE, Park KS, Choi SC, Constipation Research group of the Korean Society of Neurogastroenterology and Motility

A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride,...
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Effect of Prucalopride in the Treatment of Chronic Constipation in Asian and Non-Asian Women: A Pooled Analysis of 4 Randomized, Placebo-controlled Studies

Ke M, Tack J, Quigley EM, Zou D, Choi SC, Leelakusolvong S, Liu A, Kim J

  • KMID: 2381209
  • J Neurogastroenterol Motil.
  • 2014 Oct;20(4):458-468.
  • doi: 10.5056/jnm14029
BACKGROUND/AIMS: To compare the efficacy and safety of prucalopride, a novel selective high-affinity 5-hydroxytryptamine type 4 receptor agonist, versus placebo, in Asian and non-Asian women with chronic constipation (CC). METHODS: Data...
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Current Issues on the Treatment of Chronic Constipation

Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Shin JE, Kim SE, Park KS, Choi SC

Chronic constipation is a very common clinical problem with its prevalence of up to 14% in the general population. It is not a life-threatening disease, but since patient's satisfaction to...
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Strategy to Manage Irritable Bowel Syndrome in Korea

Kim JH, Sung IK

  • KMID: 2269332
  • Korean J Med.
  • 2014 Jun;86(6):695-697.
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between...
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The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs

Park SJ, Choi EJ, Yoon YH, Park H

PURPOSE: Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and...
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Guidelines for the Treatment of Irritable Bowel Syndrome

Kwon JG, Park KS, Park JH, Park JM, Park CH, Lee KJ, Park HJ, Rhee JC, The Korean Society of Neurogastroenterology and Motility

Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms, but they are often of limited efficacy in addressing the entire symptom complex....
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Effects of Mosapride on Upper Gastrointestinal Symptoms and Gastric Emptying in Patients with Functional Dyspepsia

Ji SW, Park H, Lee PR, Lee OY, Kim DK

  • KMID: 2255867
  • Korean J Neurogastroenterol Motil.
  • 2004 Jun;10(1):27-34.
BACKGROUND/AIMS: Mosapride is a new, prokinetic, 5-HT4 agonistic agent free of dopamine D2 receptor antagonist properties. The aim of this study was to evaluate the effects of mosapride on upper...
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