- Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke
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Sapkota A, Park SJ, Choi JW
- KMID: 2508205
- Biomol Ther.
- 2020 Nov;28(6):512-518.
- doi: 10.4062/biomolther.2020.159
Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific... -
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- Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation
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Sapkota A, Choi JW
- KMID: 2524147
- Biomol Ther.
- 2022 Jan;30(1):55-63.
- doi: 10.4062/biomolther.2021.154
Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to exert protective effects against several neurological diseases through its anti-oxidative and anti-inflammatory activities. The goal of the present study... -
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- Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis
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Sapkota A, Park SJ, Choi JW
- KMID: 2442006
- Biomol Ther.
- 2019 Feb;27(2):152-159.
- doi: 10.4062/biomolther.2018.089
Multiple sclerosis (MS) is an autoimmune disease characterized by progressive neuronal loss, neuroinflammation, axonal degeneration, and demyelination. Previous studies have reported that 6-shogaol, a major constituent of ginger (Zingiber officinale... -
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- Quantifying the effects of anomalies of temperature, precipitation, and surface water storage on diarrhea risk in Taiwan
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Andhikaputra G, Sharma A, Sapkota A, He H, Lin YK, Deng LW, Wang YC
- KMID: 2544775
- Epidemiol Health.
- 2023;45(1):e2023024.
- doi: 10.4178/epih.e2023024
OBJECTIVES: Diarrheal disease continues to be a significant cause of morbidity and mortality. We investigated how anomalies in monthly average temperature, precipitation, and surface water storage (SWS) impacted bacterial, and... -
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