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Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats

Park JM, Song MK, Kim YJ, Kim YJ

PURPOSE: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin...
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Effect of Hypertonic Seawater (Sinomarin(R)) on Mucociliary Clearance in Normal Subjects

Lee SH, Song JS, Lee SH, Hwang SJ, Lee HM

  • KMID: 2223299
  • J Rhinol.
  • 2003 Nov;10(1, 2):19-22.
BACKGROUND AND OBJECTIVES: The effect of the hypertonic nasal douching solutions on mucociliary clearance was studied to ascertain the effect of hypertonic seawater. MATERIALS AND METHODS: Twenty-eight normal subjects were...
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The Effect of Air in a Sauna on Nasal Mucociliary Function

Lee CB, Cho JS, Lim SC, Cho Y, Na AS, Jeong HS

  • KMID: 2274592
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Oct;42(10):1261-1263.
BACKGROUND AND OBJECTIVES: There has been many attempts to find out the changes in the nasal mucociliary transport function under various conditions. In this study, we intended to determine if...
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The Comparison Study of Mucociliary Clearance After Nasal Irrigation with Buffered Hypotonic, Isotonic, and Hypertonic Saline Solutions

Kim SW, Suh BD

  • KMID: 2274567
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Apr;42(4):449-454.
BACKGROUND AND OBJECTIVES: Nasal or sinus irrigation is the traditional treatment for chronic paranasal sinusitis and is the one of the most important postoperative care for those who have undergone...
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Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Park JS, Yoo SB, Kim JY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K, Jahng JW, Choi SY

The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have...
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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism

Kim HL, Ha AW, Kim WK

BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study...
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A Study of the Lacrimal Passage by the Simple Taste Test

Lee WH

  • KMID: 2122502
  • J Korean Ophthalmol Soc.
  • 1975 Dec;16(4):375-377.
A simple diagnostic test has been performed for the evaluation of the patency of the lacrimal excretory system. A 1% Saccharine solution was instilled in the lower conjuctival cul-de-sac and...
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Effects of oropharyngeal taste stimuli in the restoration of the fasting-induced activation of the HPA axis in rats

Yoo SB, Lee JH, Ryu V, Jahng JW

INTRODUCTION: This study examined the regulatory mechanism underlying the meal-induced changes in the hypothalamic-pituitary-adrenal gland (HPA) axis activity. MATERIALS AND METHODS: Male Sprague-Dawley rats (250-300 g) were hired for two different...
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Change in the Nasal Patency and Mucociliary Clearance after Phenylephrine Spray

Kwon SH, Kim JH

  • KMID: 1922546
  • Korean J Otolaryngol-Head Neck Surg.
  • 1997 Apr;40(4):574-579.
Mucociliary clearance of nasal cavity is one of the most important defense mechanism of the respiratory tract. Abnormalities in the mucociliary clearance may cause pathologic condition of nose and paranasal...
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The Effects of Alcohol on Nasal Patency and Mucociliary Clearance

Kwon SH, Seo SY

  • KMID: 2131747
  • J Rhinol.
  • 1999 Nov;6(2):140-144.
MATERIALS AND METHODS: Fifteen healthy volunteers were studied to evaluate the effects of alcohol ingestion on nasal mucosa over time and changes in mucociliary function after alcohol ingestion. Nasal patency...
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Sweet Taste-Sensing Receptors Expressed in Pancreatic beta-Cells: Sweet Molecules Act as Biased Agonists

Kojima I, Nakagawa Y, Ohtsu Y, Medina A, Nagasawa M

The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2 and T1R3. This receptor is also expressed in pancreatic beta-cells. When the expression of receptor subunits...
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Functional and Morphological Changes of the Nasal Mucosa after Radiotherapy

Kim JS, Ye MK, Kwon SW, Park JS, Seong CS, Kim JC

  • KMID: 1922500
  • Korean J Otolaryngol-Head Neck Surg.
  • 1997 Jul;40(7):1008-1013.
OBJECTIVES: To evaluate the functional and morphological changes of the nasal mucosa after radiotherapy in humans. MATERIALS & METHODS: We examined the pathology of the nasal mucociliary system by saccharine...
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Clinical course of Chronic Intractable Sinusitis in Children

Lee SJ, Ahn YM, Hur JA

  • KMID: 2314426
  • Pediatr Allergy Respir Dis.
  • 2006 Dec;16(4):335-344.
PURPOSE:Chronic intractable sinusitis is a sinus infection persisting for more than 3 months and characterized by refractoriness to conventional treatment. Despite much research on pathogenesis and treatment, its prevalence is...
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Expression of Cancer-Testis Genes in Brain Tumors

Lee MH, Son EI, Kim E, Kim IS, Yim MB, Kim SP

OBJECTIVE: Cancer-testis (CT) genes are considered promising candidates for immunotherapeutic approaches. The aim of this study was to investigate which CT genes should be targeted in immunotherapy for brain tumors. METHODS:...
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The Effect of Mitomycin C in Middle Meatal Antrostomy Site

Kim ST, Lee BY, Ko SH, Chung YS, Cho CH, Park JS, Cha HE

  • KMID: 1887275
  • Korean J Otolaryngol-Head Neck Surg.
  • 2002 Jun;45(6):585-588.
BACKGROUND AND OBJECTIVE: Adhesion and stenosis are important in causing poor results of sinus surgery. Mitomycin C (MMC) is an antibiotic-antineoplastic agent that decreases fibroblast proliferation and scar formation. This...
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Predictive Validity of Some Common Animal Models of Bipolar Disorder Using Lithium and Lamotrigine Therapy: An Attempt towards a Battery-Based Approach for the Evaluation of Mood Stabilizers

Kumar M, Tripathi C, Verma V, Padhy BM, Meshram GG, Abhilash B

OBJECTIVE: To determine the predictive validity of some of the commonly employed models of mania and depression using standard drugs i.e. lithium (70 mg/kg) and lamotrigine (5 mg/kg) in male...
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The Comparative Study of Mucociliary Clearance with Long-term Hypertonic Saline versus Normal Saline Nasal Wash of Normal Person and Patients after Endoscopic Sinus Surgery

Roh HJ, Youn SH, Kwak DH, Lee GS, Moon HS, Kim SW, Lee JD

  • KMID: 1874418
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Oct;43(10):1067-1072.
BACKGROUND AND OBJECTIVES: Nasal irrigation, a conventional therapy for both surgical and nonsurgical patients with a history of chronic rhinosinusitis, aids in the clearance of secretions, debris, and intranasal crusts....
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The Effect of Saccharin on the Gene Expression of NF-κB and Inflammatory Cytokines in LPS-Stimulated SW480 Colon Cancer Cells

Choi H, Kim S, Kang H, Kim M, Kim W

There have been no published studies concerning the anti-inflammatory effects of corn silk on colon cancer cells. Thus, this study was conducted to investigate the effect of corn silk extract...
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Effects of Low-Dose Long-Term Macrolide Therapy on the Postoperative Symptom Change, Mucociliary Clearance and Polyp Regrowth

Lim YH, Kim JM, Hwang JY, Kwon TY, Kim YB, Kim SW

  • KMID: 2131800
  • J Rhinol.
  • 2002 Nov;9(1, 2):47-51.
Low-dose long-term macrolide therapy (LDLMT) has been reported as an effective treatment in chronic respiratory tract diseases such as diffuse panbronchiolitis and chronic paranasal sinusitis. The mechanism of action of...
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