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SUMO Proteins are not Involved in TGF-beta1-induced, Smad3/4-mediated Germline alpha Transcription, but PIASy Suppresses it in CH12F3-2A B Cells

Lee SH, Kim PH, Oh SM, Park JH, Yoo YC, Lee J, Park SR

TGF-beta induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-beta signal-transducing transcription factors, mediate germline (GL) alpha transcription induced by TGF-beta1, resulting in...
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Apoptosis of Synovial Cells in Rheumatoid Arthritis

Ji JD, Yoo DH

  • KMID: 1587008
  • J Korean Rheum Assoc.
  • 2001 Mar;8(1):1-7.
Rheumatoid arthritis is characterized by a chronic inflammatory synovitis, eventually leading to destruction of bone and cartilage. Significant hyperplasia and infiltration of activated inflammatory cells play a major role...
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