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The Proportion of Rifabutin-susceptible Strains among Rifampicin- resistant Isolates and Its Specific rpoB Mutations

Lew WJ, Park YK, Kim HJ, Chang C, Bai GH, Kim SK

  • KMID: 2318662
  • Tuberc Respir Dis.
  • 2005 Sep;59(3):257-265.
BACKGROUND: Rifabutin (ansamycin) is a spiro-piperidyl rifamycin, which is highly active against Mycobacterium tuberculosis. It has been found that some clinical isolates of tubercle bacilli that are resistant to rifampicin...
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Rifabutin Related Uveitis in AIDS: A Case Report

Park YC, Lee JW, Shin JP, Kim SY

PURPOSE: To describe a case of symptomatic rifabutin-related uveitis with hypopyon and vitreous opacity in apatient with acquired immunodeficiency syndrome infected with Mycobacterium tuberculosis. CASE SUMMARY: A 33-year-old male patient with...
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Recurrent neutropenia induced by rifabutin in a renal transplant recipient

Chang JY, Jeong EG, Yu JH, Chung BH, Yang CW

  • KMID: 2070119
  • Korean J Intern Med.
  • 2014 Jul;29(4):532-534.
No abstract available.
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Rifabutin-based Fourth and Fifth-line Rescue Therapy in Patients with for Helicobacter pylori Eradication Failure

Sung J, Kim N, Park YH, Hwang YJ, Kwon S, Na G, Choi JY, Kang JB, Kim HR, Kim JW, Lee DH

BACKGROUND/AIMS: Optimized regimen has not yet been established for failures of multiple Helicobacter pylori (H. pylori) eradication. Hence, we aimed to evaluate the efficacy of rifabutin-based rescue therapy, at least...
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Cross-resistance Between Rifampicin and Rifabutin and Its Relationship with rpoB Gene Mutations in Clinically Isolated MDR-TB Strains

Kim BJ, Oh SH, Cho EJ, Park SK

  • KMID: 2318816
  • Tuberc Respir Dis.
  • 2006 Feb;60(2):171-179.
BACKGROUND: Despite the emerging danger of MDR-TB to human beings, there have only been a limited number of drugs developed to treat MDR-TB since 1970. This study investigated the cross-resistance...
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Rescue therapies for Helicobacter pylori infection after failure of proton pump inhibitor-based standard triple therapy

Seo YH, Rhie SY, Park BJ, Kim HJ, Kim JG

  • KMID: 2305881
  • Korean J Med.
  • 2008 Jan;74(1):23-29.
BACKGROUND/AIMS: Proton pump inhibitor (PPI)-based standard triple therapy for Helicobacter pylori infection is widely used, but it has a considerable failure rate. The aim of this study was to evaluate...
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Comparison of Rifabutin- and Levofloxacin-based Third-line Rescue Therapies for Helicobacter pylori

Jeong MH, Chung JW, Lee SJ, Ha M, Jeong SH, Na S, Na BS, Park SK, Kim YJ, Kwon KA, Ko KI, Jo Y, Hahm KB, Jung HY

BACKGROUND/AIMS: There is increasing need for third-line therapy of Helicobacter pylori due to increasing level of antibiotics resistance. The aim of this study was to compare rifabutin and levofloxacin rescue...
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Treatment of Helicobacter pylori

Kim KO

The seroprevalence of Helicobacter pylori (H. pylori) in Korea was found to be decreased. However eradication rate of 1st line therapy has become lower and antimicrobial resistance has increased, recently....
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Rifabutin susceptibility and rpoB gene mutations in multi-drug resistant mycobacterium tuberculosis

Shim TS, Kim JS, Park MS, Lim CM, Lee SD, Koh YS, Kim WS, Kim DS, Kim WD

BACKGROUND: Following several decades of decline, the incidence of tuberculosis has recently begun to increase in many countries and the control of this disease has been impeded by the emergence...
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A Case of Vertebral Osteomyelitis With Epidural Abscess Caused by Mycobacterium intracellulare in a Rheumatoid Arthritis Patient

Kim HS, Kim J, Choi JI, Yoon HJ, Kim JH, Kim YS, Kwak DS, Lee JK, Lee S, Pai H

Mycobacterium avium complex (MAC) is the most common pathogen in nontuberculous mycobacterial lung diseases, but vertebral osteomyelitis caused by MAC is rare. We experienced a case of vertebral osteomyelitis with...
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Development of Multidrug Resistance during Standardized Treatment in a Patient with Drug-Sensitive Tuberculosis

Jeong YJ, Kang HJ, Choi SM, Han SK, Yim JJ

  • KMID: 2263562
  • Korean J Med.
  • 2012 May;82(5):614-617.
Standard short-course chemotherapy (SSC) is recommended for new patients with pulmonary tuberculosis (TB). This approach has been regarded as among the most effective tools for preventing the development of resistance...
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Detection of Point Mutations in the rpoB gene Related to Drug Susceptibility in Mycobacterium Tuberculosis using an Oligonucleotide Chip

Kim HJ, Kim SK, Shim TS, Park YD, Park M

BACKGROUND: The appearance of multiple-drug-resistant Mycobacterium tuberculosis strains has been seriously compromising successful control of tuberculosis. Rifampin-resistance, caused by mutations in the rpoB gene, can be indicative of multiple-drug-resistance, and...
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Recent Update on Third-line Helicobacter pylori Eradication

Kim JH

The eradication rate of Helicobacter pylori has been decreasing progressively, primarily due to increased resistance to antibiotics. The widely used standard clarithromycin-based triple therapy regimen is no longer achieving eradication...
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Mycobacterium avium Complex Peritonitis in an Acquired Immune Deficiency Syndrome Patient

Jung H, Kim YJ, Shin S, Lee SA, Kim MJ, Chang HH, Kim SW

Mycobacterium avium complex (MAC) is an opportunistic bacterium that primarily infects acquired immune deficiency syndrome (AIDS) patients with low CD4+ T cell counts; however, peritonitis caused by MAC in AIDS...
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Current concepts in the treatment of H. pylori infection and H. pylori vaccines

Eun CS, Han DS

  • KMID: 1523328
  • Hanyang Med Rev.
  • 2007 Aug;27(3):92-102.
Seven day regimen of proton pump inhibitor (PPI)-clarithromycin-amoxicillin triple therapy has been the main first line therapy for H. pylori infection. However, recently, the efficacy of this triple therapy becomes...
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Historical Perspective of Helicobacter pylori Treatment in Korea

Lee JY, Ahn JY, Choi IJ

Since the discovery of Helicobacter pylori in 1983 by Warren and Marshall, it has been recognized as one of the most significant risk factors for gastric cancer and has been...
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Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage

Park S, Park JA, Jeon JH, Lee Y

HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in...
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Comparison of the Antibiotic Resistance of Helicobacter pylori Isolated in Jinju Over a 15-year Period

Seo JH, Koo SI, Youn HS, Jun JS, Lim JY, Park CH, Woo HO, Kang HL, Baik SC, Lee WK, Cho MJ, Rhee KH

The aims of this study were to investigate the changing pattern of Helicobacter pylori antibiotic resistance in Jinju over a 15-year period. H. pylori strains were isolated from 170 adults...
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