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Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines

Choi KS

Recent advances in reverse genetics techniques make it possible to manipulate the genome of RNA viruses such as Newcastle disease virus (NDV). Several NDV vaccine strains have been used as...
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Protective efficacy of a high-growth reassortant swine H3N2 inactivated vaccine constructed by reverse genetic manipulation

Wen F, Ma JH, Yu H, Yang FR, Huang M, Zhou YJ, Li ZJ, Tong GZ

Novel reassortant H3N2 swine influenza viruses (SwIV) with the matrix gene from the 2009 H1N1 pandemic virus have been isolated in many countries as well as during outbreaks in multiple...
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New Vaccine Technology for Control of Emerging and Reemerging Infectious Diseases

Kang JH

  • KMID: 2303880
  • Korean J Epidemiol.
  • 2006 Jun;28(1):41-46.
Although the development of vaccines has been one of the most important contributions of immunology to medicine and public health, and despite vaccination having been proven as the most effective...
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Oral immunization of mice with recombinant rabies vaccine strain (ERAG3G) induces complete protection

Yang DK, Kim HH, Choi SS, Kim JT, Jeong WH, Song JY

PURPOSE: New rabies vaccine bait for both pets and raccoon dogs residing in Korea is needed to eradicate rabies infection among animals. In this study, we constructed a recombinant rabies...
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A recombinant rabies virus (ERAGS) for use in a bait vaccine for swine

Yang DK, Kim HH, Choi SS, Lee SH, Cho IS

PURPOSE: Rabies viruses (RABV) circulating worldwide in various carnivores occasionally cause fatal encephalitis in swine. In this study, the safety and immunogenicity of a recombinant rabies virus, the ERAGS strain...
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H5 and H9 subtypes of Avian Influenza Viruses are Real Threat To Humans

Seo SH

  • KMID: 1515466
  • Infect Chemother.
  • 2004 May;36(Suppl 1):S6-S9.
Recent outbreaks of H5N1 avian influenza viruses in most Asian countries alert the imminent pandemic. Twenty-three humans out of 34 confirmed cases were dead of H5N1 infections. H9N2 avian influenza...
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Immunohistochemical Staining with Anti-Torpedo Dystrophin Antibody in Duchenne Type Muscular Dystrophy

Kim SY, Lee KW, Cha CI

  • KMID: 2065956
  • J Korean Neurol Assoc.
  • 1993 Mar;11(1):68-77.
Duchenne Muscular dystrophy(DMD) is a debilitating X-linked muscle disease and dyskophin is a muscle membrane protein, which is recently discovered through reverse genetics by Kunkel et al(1987). We evaluate the...
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Requirements for improved vaccines against foot-and-mouth disease epidemics

Park JH

  • KMID: 2391970
  • Clin Exp Vaccine Res.
  • 2013 Jan;2(1):8-18.
Inactivated foot-and-mouth disease (FMD) vaccines are currently used worldwide. With the emergence of various FMD virus serotypes and subtypes, vaccines must become more suitable for field-based uses under the current...
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Principles underlying rational design of live attenuated influenza vaccines

Jang YH, Seong BL

Despite recent innovative advances in molecular virology and the developments of vaccines, influenza virus remains a serious burden for human health. Vaccination has been considered a primary countermeasure for prevention...
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Generation of NS1-mutant Live attenuated Human Influenza vaccine candidate

Cheong HJ, Xiao S, Palese P

  • KMID: 2285116
  • Infect Chemother.
  • 2004 Aug;36(4):189-196.
BACKGROUND:Influenza virus reverse genetics has reached a level of sophistication where one can confidently generate virus entirely form cloned cDNA. This system makes it possible to generate attenuated live virus...
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Construction of A Stable Full-Length cDNA Clone of Japanese Encephalitis Virus Strain SA14-14-2 Using Low Copy Number Plasmid

Min KI, Kim YM, Choo MS, Baek SY, Kim JO, Ryu SR, Min BS, Kim Y, Park MK, Byeon WH, Hur SJ

  • KMID: 1579128
  • J Bacteriol Virol.
  • 2004 Dec;34(4):339-353.
Recently the reverse genetics system contributed to the progresses in the investigation of positive-stranded RNA viruses. Here, we report the successful construction of a stable full-length infectious cDNA clone of...
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