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Current Assessment and Management of Retinoblastoma

Chueh HW

Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment. However, evaluations for...
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Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer

Wang Z, Gao J, Zhou J, Liu H, Xu C

OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP...
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Development of a Novel Nonradioisotopic Assay and Cdc25B Overexpression Cell Lines for Use in Screening for Cdc25B Inhibitors

Ha GS, Lee CM, Kim CW

PURPOSE: The cyclin-dependent kinase 1 (Cdk1) and cyclin B complex performs important roles in the transition from the G2 to M phase in the cell cycle through removal of inhibitory...
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Mammary-Type Myofibroblastoma: A Report of Two Cases

An S, Song JS, Park S, Lee JW, Cho KJ

Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to...
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Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27

Kim JH, Choi YK, Byun JK, Kim MK, Kang YN, Kim SH, Lee S, Jang BK, Park KG

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) regulates cell growth and tumorigenesis in various cancers. However, the clinical relevance of ERRγ to hepatocellular carcinoma (HCC) remains unclear. Here we examined...
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Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells

Han JH, Kim Y, Jung SH, Lee JJ, Park HS, Song GY, Cuong NM, Kim YH, Myung CS

The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF)...
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Clinical Relevance of High-Resolution Single Nucleotide Polymorphism Array in Patients with Relapsed Acute Lymphoblastic Leukemia with Normal Karyotype: A Report of Three Cases

Park SH, Lee SH, Kim SY, Lee SM, Yi J, Kim IS, Kim HH, Chang CL, Lee EY

We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated...
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A Rare Case of Transformation of Childhood Myelodysplastic Syndrome to Acute Lymphoblastic Leukemia

Koh YR, Cho EH, Park SS, Park MY, Lee SM, Kim IS, Lee EY

Transformation of MDS into ALL during childhood is extremely rare. We report a rare case of an 8-yr-old girl who presented with refractory cytopenia of childhood (RCC) that transformed into...
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p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb

Yun UJ, Park SE, Shin DY

Cellular senescence is a tumor-suppressive process instigated by proliferation in the absence of telomere replication, by cellular stresses such as oncogene activation, or by activation of the tumor suppressor proteins,...
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Expression of pRb, p53, p16 and Cyclin D1 and Their Clinical Implications in Urothelial Carcinoma

Lee K, Jung ES, Choi YJ, Lee KY, Lee A

The aim of this study was to assess immunohistochemical expression of p53, pRb, p16, and cyclin D1, alone or in combination, as prognostic indicators and to investigate their correlation with...
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Prognostic Role of Rb, p16, Cyclin D1 Proteins in Soft Tissue Sarcomas

Shim BY, Yoo J, Lee YS, Hong YS, Kim HK, Kang JH

  • KMID: 2270803
  • Cancer Res Treat.
  • 2010 Sep;42(3):144-150.
PURPOSE: The aim of this study was to determine the expressions of Rb, p16, and cyclin D1 in soft tissue sarcomas, and we also wanted to identify the prognostic factors...
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p16(INK4A) promoter hypermethylation and expression of p16(INK4A), cyclin D1, and Rb in papillary thyroid carcinoma

Kim YJ, Kim HS, Ha YJ, Lee HY, Park KG, Kim MK, Kwon SY

  • KMID: 2259183
  • Korean J Med.
  • 2010 Mar;78(3):333-340.
BACKGROUND/AIMS: Dysregulation of the cell cycle is believed to be important in human neoplasia. p16(INK4A), a regulator of the retinoblastoma protein, is inactivated by several mechanisms, including hypermethylation of the...
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Expression Profiles of Retinoblastoma Protein and p27Kip1 According to HER2 Amplification Status in Primary Breast Cancer

Shin JH, Park SJ, Cho HJ, Gwak G, Bae BN, Kim KW, Kim HY, Park K, Han S

PURPOSE: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to...
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Functional Inactivation of pRb Associated with Cyclin D1- and Cyclin-dependent Kinase 4 Overexpression Plays A Key Role in Human Pituitary Tumorigenesis

Myong NH

BACKGROUND: Human pituitary adenoma (PA) is a common intracranial tumor, but the mechanism underlying tumorigenesis has not been established. Functional inactivation of retinoblastoma protein (pRb) following cyclin D1- and cyclin-dependent...
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Cyclin D1 Overexpression, p16 Loss, and pRb Inactivation Play a Key Role in Pulmonary Carcinogenesis and have a Prognostic Implication for the Long-term Survival in Non-small Cell Lung Carcinoma Patients

Myong NH

  • KMID: 2166001
  • Cancer Res Treat.
  • 2008 Jun;40(2):45-52.
PURPOSE: We investigated the immunoexpressions of cyclin D1, cyclin-dependent kinase inhibitor p16 and phosphorylated retinoblastoma (p-pRb) proteins in non- small cell lung carcinoma (NSCLC) to demonstrate their key roles in...
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Role of Akt in Tumorigenesis and Angiogenesis of MC-SV-HUC T2 Cell Line

Kim MK

  • KMID: 1484901
  • Korean J Anat.
  • 2008 Jun;41(2):111-119.
Protein Kinase B (PKB/Akt) is a serine/threonine kinase that plays important roles in multiple physiological and pathological processes. Specially, Akt activation induces tumorigenesis in many cancers. However, molecular mechanism related...
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A study on the expression of p16 gene, methylation of p16 gene promoter and HPV typing in uterine cervical neoplasia

Jeon S, Choi SD, Bae DH, Jeong DJ, Kim CJ, Shin YW

  • KMID: 2244549
  • Korean J Gynecol Oncol.
  • 2007 Sep;18(3):201-208.
OBJECTIVE: p16 is cyclin-dependent kinase (CDK) inhibitor which decelerates cell cycle by inactivating CDKs that phosphorylate retinoblastoma protein (pRb). In cervical carcinogenesis, abnormality of p16 gene such as methylation of...
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Aberrant Cell Cycle Regulation in Cervical Carcinoma

Kim YT, Zhao M

Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However,...
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Degradation of the Retinoblastoma Tumor Suppressor Protein by the Human Papillomavirus-16 E7 Variants

Tae SH, Choi CH, Choi EJ, Cho YL, Lee JC, Seol SY, Cho DT, Lee YC

  • KMID: 1574118
  • J Bacteriol Virol.
  • 2005 Jun;35(2):141-148.
Human papillomavirus type 16 (HPV-16) plays an etiological role in benign and malignant epithelial tumors. A critical event in HPV transformation of human cells is the inactivation of retinoblastoma protein...
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Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer

Song HS, Kim IH, Sohn SS, Kwon KY, Lee WS

BACKGROUND: The aim of this study was to determine the prognostic significance of the expression of p53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by...
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