- Current Assessment and Management of Retinoblastoma
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Chueh HW
- KMID: 2449229
- Clin Pediatr Hematol Oncol.
- 2019 Apr;26(1):35-45.
- doi: 10.15264/cpho.2019.26.1.35
Retinoblastoma is the most common intraocular malignancy in childhood. Diagnosis is currently made by ophthalmologists under general anesthesia as it is the gold standard for intraocular assessment. However, evaluations for... -
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- The Role of N-terminal Truncated Retinoblastoma Protein (pRb94) in Transcriptional Regulation of the Hepatitis B Virus X-protein in Human Hepatoma Cells
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Lee SD, Choi SY
- KMID: 2117041
- J Korean Surg Soc.
- 1999 Mar;56(3):319-325.
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths in the world, especially in Korea where 6-12% of the general population show positive for HbsAg. The... -
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- An Experimental Study of the Effect of TGF-beta1 on the Growth and Apoptosis in Y-79 Retinoblastoma Cells
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Lee MA, Kwak HW, Jin KH, Kim JM
- KMID: 2205683
- J Korean Ophthalmol Soc.
- 1999 Dec;40(12):3368-3376.
The effect of TGF-beta1 on the growth of Y-79 retinoblastoma cells was examined. Y-79 retinoblastoma cells treated with TGF-beta1[0.5 ng/ml, 1.0ng/ml] were cultured and their growth curve was compared to... -
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- p16(INK4A) promoter hypermethylation and expression of p16(INK4A), cyclin D1, and Rb in papillary thyroid carcinoma
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Kim YJ, Kim HS, Ha YJ, Lee HY, Park KG, Kim MK, Kwon SY
- KMID: 2259183
- Korean J Med.
- 2010 Mar;78(3):333-340.
BACKGROUND/AIMS: Dysregulation of the cell cycle is believed to be important in human neoplasia. p16(INK4A), a regulator of the retinoblastoma protein, is inactivated by several mechanisms, including hypermethylation of the... -
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- Expression of Retinoblastoma Protein in Cutaneous Squamous Cell Carcinomas and Basal Cell Carcinomas
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Cho SY, Ahn HB, Kim DY, Lee SY, Cho BH
- KMID: 2322490
- J Korean Soc Plast Reconstr Surg.
- 1999 Mar;26(2):199-203.
There is increasing evidence that inactivation of tumor-suppressor genes can promote tumor growth. Retinoblastoma protein (pRb) is the product of the retinoblastoma gene located on chromosome 13q14. pRb negatively regulates... -
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- Comparative Analysis of the Expression of p53, Rb, PCNA in thc Gastric Carcinoma
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Lee S, Moon B, Choi SK, Rew CS, Yoon CM, Park CS
- KMID: 2080536
- Korean J Med.
- 1997 Jun;52(6):846-857.
OBJECTIVES: Recently, the studies for oncogene and tumor marker have been actively performed to investigate the carcinogenesis of gastric carcinoma, but it is not clearly understood. We investigated the expression... -
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- Altered Retinoblastoma Protein Expression and Proliferative Activity in Urethane Induced Mouse Lung Tumorigenesis
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Chung JH, Jang JJ, Lee MJ, Ham EK
- KMID: 1804464
- Cancer Res Treat.
- 2002 Aug;34(4):258-263.
Lung cancer develops through a multistage process involving the accumulation of diverse genetic alterations. To gain an understanding of the roles played by tumor suppressor gene proteins and proliferating cell... -
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- Degradation of the Retinoblastoma Tumor Suppressor Protein by the Human Papillomavirus-16 E7 Variants
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Tae SH, Choi CH, Choi EJ, Cho YL, Lee JC, Seol SY, Cho DT, Lee YC
- KMID: 1574118
- J Bacteriol Virol.
- 2005 Jun;35(2):141-148.
Human papillomavirus type 16 (HPV-16) plays an etiological role in benign and malignant epithelial tumors. A critical event in HPV transformation of human cells is the inactivation of retinoblastoma protein... -
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- Expression of Cyclin D1, CDK4, p16 and Rb Proteins in Human Soft Tissue Sarcomas
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Yoo J, Lee AW, Kang SJ, Kim BK
- KMID: 2275610
- Korean J Pathol.
- 2001 Jun;35(3):238-244.
BACKGROUND: Altered cell cycle regulation may underlie the development and/or progression of human malignancies. The purpose of this study is to determine if the oncogenesis of soft tissue sarcomas could... -
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- Correlation between p53 and Rb Protein Expression and Clinicopathologic Features in Hepatocellular Carcinoma
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Gu MJ, Choi JH
- KMID: 1972873
- Cancer Res Treat.
- 2003 Dec;35(6):514-520.
PURPOSE: Hepatocellular carcinomas (HCC) are one of the most common cancers in Korea. The mechanism of HCC development is still unclear, and the aberration of the tumor suppressor genes in... -
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- Functional Inactivation of pRb Associated with Cyclin D1- and Cyclin-dependent Kinase 4 Overexpression Plays A Key Role in Human Pituitary Tumorigenesis
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Myong NH
- KMID: 1472555
- Korean J Pathol.
- 2009 Feb;43(1):56-62.
- doi: 10.4132/KoreanJPathol.2009.43.1.56
BACKGROUND: Human pituitary adenoma (PA) is a common intracranial tumor, but the mechanism underlying tumorigenesis has not been established. Functional inactivation of retinoblastoma protein (pRb) following cyclin D1- and cyclin-dependent... -
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- Expression of p16 and Rb in 9,10-Dimethyl-1,2-Benzanthracene Induced Rat Ovarian Carcinogenesis
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Kim KK, Kim DH
- KMID: 2275645
- Korean J Pathol.
- 2001 Apr;35(2):144-150.
BACKGROUND: In order to investigate the roles of p16 and Rb, their expression was evaluated in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced ovarian cancers of rats. METHODS: DMBA-coated silk was inserted into both ovaries... -
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- Expression of pRb, p16, Cyclin D1 and Cyclin E in Infiltrating Duct Carcinoma of the Breast
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Hur HK, Roh MS, Jeong JS, Rha SH, Huh GY, Hong SH
- KMID: 1725835
- Korean J Pathol.
- 2001 Oct;35(5):416-423.
BACKGROUND: Inactivation of the retinoblastoma protein (pRb) is a mechanism by which tumor cells can subdue normal growth control. Among the molecules involved in control of pRb phosphorylation, cyclin D1... -
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- Relationship between E2F1 Expression and Clinical Outcome in Node-Positive Breast Cancer
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Kwak KH, Bae BN, Kim KH, Kim HJ, Kim YD, Kim HY, Park KM, Han SH
- KMID: 2006624
- J Korean Breast Cancer Soc.
- 2003 Sep;6(3):155-160.
- doi: 10.4048/jkbcs.2003.6.3.155
PURPOSE: This study was performed to investigate whether the E2F1 protein expression can be used as a prognostic factor in clinical breast cancer. METHODS: The expressions of E2F1 and retinoblastoma... -
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- Expression of p53 and Rb Proteins in Invasive Ductal Carcinoma of the Breast
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Son HJ, Yoon HS, Kang MJ
- KMID: 2011650
- Korean J Pathol.
- 1999 Jun;33(6):443-449.
Inactivation of tumor suppressor genes may play an important role in many human cancers including breast. This study was done to determine the relationship between the expression of p53 and... -
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- A Study on Expression Pattern of p53, Rb Gene and Apoptosis in Ovarian Epithelial Borderline Tumors and Invasive Carcinoma
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Ha MW, Ko HK, Kang GJ, Yoon MS, Sol MY
- KMID: 2269976
- Korean J Obstet Gynecol.
- 2000 Mar;43(3):407-413.
OBJECTIVE: The aim of this study is to evaluate the role of tumor suppressor genes, p53 and Rb gene, as well as apoptosis in the carcinogenesis of ovarian epithelial tumors.... -
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- Significance of Expression of p16, Cyclin D1, Rb, and p53 Protein and Correlation with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast
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Lee MJ, Jeon HJ, Kim KC
- KMID: 1979394
- Korean J Pathol.
- 2000 Apr;34(4):288-299.
The retinoblastoma (Rb)/cyclin D1/p16 pathway is an important constituent of cell cycle regulation. Perturbations in this pathway due to a variety of genetic aberrations have been reported in many human... -
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- Expression Profiles of Retinoblastoma Protein and p27Kip1 According to HER2 Amplification Status in Primary Breast Cancer
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Shin JH, Park SJ, Cho HJ, Gwak G, Bae BN, Kim KW, Kim HY, Park K, Han S
- KMID: 2286573
- J Breast Cancer.
- 2009 Mar;12(1):14-19.
- doi: 10.4048/jbc.2009.12.1.14
PURPOSE: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to... -
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- p53 Mutation and Expression of Rb Protein in Germ Cell Tumors
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Lee JH, Cho MY, Lee HH, Yeom BW, Won NH
- KMID: 2275702
- Korean J Pathol.
- 1998 Dec;32(12):1074-1080.
We investigated the role of the tumor suppressor genes in the germ cell tumor. Immunohistochemistry (IHC) and polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) for p53 mutation were done in... -
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- Suppression of Steroid Receptor Function by Retinoblastoma Protein in Breast Cancer Cell Line, MCF 7
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Song J, Cho SJ, Lee KI, Kim SH, Kang JS, Lee KW, Lee JY, Ku PS
- KMID: 2075581
- Korean J Obstet Gynecol.
- 1997 Oct;40(10):2269-2278.
Cancer results from mutations that disrupt the harmonious checks and balances that regulate normal cellular growth and development. These mutations arise in two classes of interacting genes:those that facilitate cell... -
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