- The Regulatory Effects of Trans-chalcone on Adipogenesis
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Han Y
- KMID: 2437482
- Int J Oral Biol.
- 2018 Mar;43(1):29-35.
- doi: 10.11620/IJOB.2018.43.1.029
It is noted that chalcone derivatives have characteristic diverse pharmacological properties, and that precise evidence has been growing that they could regulate a tumor necrosis factor-α (TNF-α) induced insulin resistance.... -
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- Identification of a mutation in the human raloxifene response element of the transforming growth factor-3 gene
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Han KO, Kang YS, Hwang CS, Moon IG, Yim CH, Chung HY, Jang HC, Yoon HK, Han IK, Choi YK
- KMID: 2157560
- J Korean Med Sci.
- 2001 Oct;16(5):549-552.
- doi: 10.3346/jkms.2001.16.5.549
The human transforming growth factor-3 (TGF-3) is an important cytokine to maintain bone mass by inhibiting osteoclast differentiation. Recently raloxifene response element (RRE), a new enhancer with a polypurine sequence... -
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- CREB-Phosphorylation as a Predictor of Therapeutic Response to Antidepressants
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Lee YJ, Lim SW, Kim SY, Jung JW, Kim JW, Myung WJ, Song JH, Kim DK
- KMID: 1462766
- J Korean Geriatr Psychiatry.
- 2010 Jun;14(1):38-43.
OBJECTIVES: CREB (c-AMP response element binding protein) is known as a key mediator of the therapeutic response to antidepressants. We investigated the change of CREB-phosphorylation (pCREB) at the early point... -
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- Expressional Regulation of Cancer Metastasis Related Gene, MMP-9, by Resveratrol
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Woo JH, Kim YH, Baek WK, Suh SI, Suh MH, Park JW, Kwon TK
- KMID: 1615505
- J Bacteriol Virol.
- 2003 Sep;33(3):235-243.
Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with the expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction... -
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- The comparative assessment of nuclear run on of hydrophilic and hydrophobic surfactant protein by administration of steroid
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Kim MO, Kim TH, Sohn JW, Yoon HJ, Shin DH, Park SS
- KMID: 1984683
- Korean J Med.
- 2006 Jan;70(1):53-60.
BACKGROUND: Surfactant proteins are important in the regulation of the surfactant secretion, synthesis and recycling. Glucocorticoids are known to have primary or secondary effects on gene expression and can alter... -
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- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
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Yeo CD, Kang N, Choi SY, Kim BN, Park CK, Kim JW, Kim YK, Kim SJ
- KMID: 2387703
- Korean J Intern Med.
- 2017 Jul;32(4):589-599.
- doi: 10.3904/kjim.2016.302
A hypoxic microenvironment leads to cancer progression and increases the metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. The hypoxic response pathway can... -
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- Characterization of Cyclic AMP Response Element (CRE) in the Promoter of the Rat Thyrotropin Releasing Hormone (TRH) Gene
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Jung WW, Yang IM, Seo KS, Jung SW
- KMID: 2461510
- J Korean Soc Endocrinol.
- 1994 Sep;9(3):190-199.
We investigated whether the two variant elements of CRE(TGcCGTCA[5'CRE], TGACcTCA[3'CRE]) in the 5'flanking region of the rat TRH gene, which are different from the CRE consensus sequence(5'-TGACGTCA-3') by one base... -
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- Epistatic Interactions between CREB and CREM Variants in Affective Disorder
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Chiesa A, Marsano A, Han C, Lee SJ, Patkar AA, Pae CU, Serretti A
- KMID: 1994612
- Psychiatry Investig.
- 2014 Apr;11(2):200-203.
- doi: 10.4306/pi.2014.11.2.200
The aim of the present work is to investigate the existence of epistatic interactions possibly influencing psychotropic agents' response between rs6740584 within Cyclic adenosine monophosphate Response Element Binding (CREB) and... -
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- Human SNF2L Gene Is Regulated Constitutively and Inducibly in Neural Cells via a cAMP-Response Element
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Xia Y, Wang L, Ma C, Gong Y, Zhao Y
- KMID: 1727896
- Yonsei Med J.
- 2013 May;54(3):772-777.
- doi: 10.3349/ymj.2013.54.3.772
PURPOSE: SNF2L belongs to Imitation Switch family and plays an essential role in neural tissues and gonads. In our previous studies, we have demonstrated that the basal transcription of human... -
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- Ethanol Extract of Cirsium japonicum var. ussuriense Kitamura Exhibits the Activation of Nuclear Factor Erythroid 2-Related Factor 2-dependent Antioxidant Response Element and Protects Human Keratinocyte HaCaT Cells Against Oxidative DNA Damage
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Yoo OK, Choi BY, Park JO, Lee JW, Park BK, Joo CG, Heo HJ, Keum YS
- KMID: 2161526
- J Cancer Prev.
- 2016 Mar;21(1):66-72.
- doi: 10.15430/JCP.2016.21.1.66
Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular... -
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- CREB Expression in Peripheral Lymphocyte and Antidepressant Response
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Shin JY, Lim SW, Chung SH, Kim H, Kim DK
- KMID: 2286982
- Korean J Psychopharmacol.
- 2004 Dec;15(4):440-448.
OBJECTIVE: The molecules related with the intracellular signal transduction system are one of the main targets for the mode of mechanisms of antidepressant treatment in depressive patients. In vivo and... -
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- Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells
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Min G
- KMID: 994396
- Exp Mol Med.
- 2010 Nov;42(11):731-738.
- doi: 10.3858/emm.2010.42.11.074
The nuclear receptors, steroid and xenobiotic receptor (SXR) and constitutive androstane receptor (CAR) play important functions in mediating lipid and drug metabolism in the liver. The present study demonstrates modulatory... -
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- Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
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Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK
- KMID: 2285575
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):327-334.
- doi: 10.4196/kjpp.2015.19.4.327
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1... -
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- Long-term and stable correction of uremic anemia by intramuscular injection of plasmids containing hypoxia-regulated system of erythropoietin expression
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Sun J, Wang Y, Yang J, Du D, Li Z, Wei J, Yang A
- KMID: 1401759
- Exp Mol Med.
- 2012 Nov;44(11):674-683.
Relative deficiency in production of glycoprotein hormone erythropoietin (Epo) is a major cause of renal anemia. This study planned to investigate whether the hypoxia-regulated system of Epo expression, constructed by... -
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- miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
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Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ
- KMID: 2361513
- Exp Mol Med.
- 2016 Apr;48(4):e226.
- doi: 10.1038/emm.2016.3
Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by... -
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- Identification of TPA - Response Element (TRE) in the Rat Thyrotropin - Releasing Hormone (TRH) Gene
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Jung WW, Choi YK, Yang IM, Seo KS, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK, Park SJ
- KMID: 2461565
- J Korean Soc Endocrinol.
- 1994 Sep;10(3):200-213.
There are two potential imperfect copies of the TRE consensus sequence between -47 and -113bp position on 5' upstream of the rat TRH gene. The upstream element(5'-TGcCgTCA-3') is located between... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Thyroid Hormone Receptor Dynamics in Thyroid Hormone Response Elements of the Human Type 1 Iodothyronine Deiodinase Gene
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Lee SJ, Park CY, Jeong IK, Hong EG, Choi CS, Kim HK, Kim DM, Yoo JM, Ihm SH, Choi MG, Yoo HJ, Park SW, Larsen PR
- KMID: 2200307
- J Korean Soc Endocrinol.
- 2003 Jun;18(3):283-295.
BACKGROUND: Type 1 iodothyronine deiodinase (D1), the product of the hdio1 gene, is involved in thyroid hormone activation by the deiodination of thyroxine (T4) to form 3, 5, 3'-triiodothyronine (T3).... -
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- Integrated computational approach to the analysis of RNA-seq data reveals new transcriptional regulators of psoriasis
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Zolotarenko A, Chekalin E, Mesentsev , Kiseleva L, Gribanova , Mehta R, Baranova A, Tatarinova TV, Piruzian E, Bruskin S
- KMID: 2362292
- Exp Mol Med.
- 2016 Nov;48(11):e268.
- doi: 10.1038/emm.2016.97
Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis... -
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