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Ethanol Extract of Cirsium japonicum var. ussuriense Kitamura Exhibits the Activation of Nuclear Factor Erythroid 2-Related Factor 2-dependent Antioxidant Response Element and Protects Human Keratinocyte HaCaT Cells Against Oxidative DNA Damage

Yoo OK, Choi BY, Park JO, Lee JW, Park BK, Joo CG, Heo HJ, Keum YS

Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular...
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Immunohistochemical Expression of Nuclear Retinoid Receptor and CREB(cAMP Response Element Binding Protein) in Lung Cancers

Shin JW, Paik KH, Choi W, Park IW, Kim MK

  • KMID: 2318749
  • Tuberc Respir Dis.
  • 2005 Dec;59(6):631-637.
BACKGROUND: Transcriptional factors of the CREB(cAMP Response Element Binding Protein) are involved in the regulation of gene expression in response to a variety of signaling pathways. Proteins produced by the...
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The Effect of T3 on Thyroid Hormone Receptor Dynamics in Thyroid Hormone Response Element of Chicken Lysozyme Silencer

Lee SJ, Park CY, Jeong IK, Hong EG, Choi CS, Kim HK, Kim DM, Yoo JM, Ihm SH, Choi MG, Yoo HJ, Park SW, Larsen PR

  • KMID: 2200383
  • J Korean Soc Endocrinol.
  • 2003 Aug;18(4):379-391.
BACKGROUND: The regulation of gene transcription can be controlled by both positive (enhancer) and negative (silencer) regulatory sequences. Several enhancer and silencer elements have been described in the 5' region...
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Thyroid Hormone Receptor Dynamics in Thyroid Hormone Response Elements of the Human Type 1 Iodothyronine Deiodinase Gene

Lee SJ, Park CY, Jeong IK, Hong EG, Choi CS, Kim HK, Kim DM, Yoo JM, Ihm SH, Choi MG, Yoo HJ, Park SW, Larsen PR

  • KMID: 2200307
  • J Korean Soc Endocrinol.
  • 2003 Jun;18(3):283-295.
BACKGROUND: Type 1 iodothyronine deiodinase (D1), the product of the hdio1 gene, is involved in thyroid hormone activation by the deiodination of thyroxine (T4) to form 3, 5, 3'-triiodothyronine (T3)....
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Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells

Kim SA, Hong KJ

  • KMID: 755077
  • Exp Mol Med.
  • 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in...
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Analysis of Glucocorticoid Response Element and TPA Response Element of Rat Thyrotropin-Releasing Hormine Gene by Site-Directed Mutagenesis

Kim SW, Kim JW, Kim YS, Choi YK, Yang IM, Woo JT, Chung WW

  • KMID: 2199458
  • J Korean Soc Endocrinol.
  • 1999 Jun;14(2):278-292.
BACKGROUND: We previously demonstrated that a GRE/TRE composite sequence, which is located between 200 bp and 220 bp relative to the transcriptional start site of rat TRH gene, is responsible...
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Chronic Antidepressant Administration Increases the Expression of PhosphoCREB(Phosphorylated Cyclic AMP Response Element Binding Protein) in Rat Hippocampus

Kim SY, Han JH, Lee CU, Paik IH

  • KMID: 2340212
  • J Korean Neuropsychiatr Assoc.
  • 1998 Sep;37(5):992-998.
OBJECTIVES: This study designed to assess the expression of phosphoCREB in rat hippocampus after chronic administration of various antidepressants in comparison with chronic administration of antipsychotic and antianxiety drugs. METHODS: Male...
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Identification of TPA - Response Element (TRE) in the Rat Thyrotropin - Releasing Hormone (TRH) Gene

Jung WW, Choi YK, Yang IM, Seo KS, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK, Park SJ

  • KMID: 2461565
  • J Korean Soc Endocrinol.
  • 1994 Sep;10(3):200-213.
There are two potential imperfect copies of the TRE consensus sequence between -47 and -113bp position on 5' upstream of the rat TRH gene. The upstream element(5'-TGcCgTCA-3') is located between...
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Characterization of Cyclic AMP Response Element (CRE) in the Promoter of the Rat Thyrotropin Releasing Hormone (TRH) Gene

Jung WW, Yang IM, Seo KS, Jung SW

  • KMID: 2461510
  • J Korean Soc Endocrinol.
  • 1994 Sep;9(3):190-199.
We investigated whether the two variant elements of CRE(TGcCGTCA[5'CRE], TGACcTCA[3'CRE]) in the 5'flanking region of the rat TRH gene, which are different from the CRE consensus sequence(5'-TGACGTCA-3') by one base...
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