- Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
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Kim H, Kim M, Im SK, Fang S
- KMID: 2459290
- Lab Anim Res.
- 2018 Dec;34(4):147-159.
- doi: 10.5625/lar.2018.34.4.147
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as... -
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- Functional Study of Gene using Inducible Cre System
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Kim JE
- KMID: 1511984
- J Korean Endocr Soc.
- 2006 Oct;21(5):364-369.
- doi: 10.3803/jkes.2006.21.5.364
Gene manipulation by disrupting important genes using homologous recombination in mammals has provided important insights into their function and development with regard to disease. However, many questions related to the... -
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- Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation
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Hwang J, Cho ES, Yang Y
- KMID: 2430472
- J Korean Acad Pediatr Dent.
- 2018 May;45(2):144-153.
- doi: 10.5933/JKAPD.2018.45.2.144
The aim of this study was to understand the roles of Sonic Hedgehog (SHH) signaling during tooth root and periodontium formation. In this study, we generated the dental mesenchyme-specific Smoothened... -
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- The Role of Autonomous Wntless in Odontoblastic Differentiation of Mouse Dental Pulp Cells
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Choi H, Kim TH, Ko SO, Cho ES
- KMID: 2382973
- J Korean Dent Sci.
- 2016 Jun;9(1):9-18.
- doi: 10.5856/JKDS.2016.9.1.9
PURPOSE: Wnt signaling plays an essential role in the dental epithelium and mesenchyme during tooth morphogenesis. Deletion of the Wntless (Wls) gene in odontoblasts appears to reduce canonical Wnt activity,... -
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- Antiangiogenic Therapy Impedes Infiltration by CD4+ and CD8+ Cells Into an Early Colon Tumor
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Yang YJ, Choi JS, Choi JW
- KMID: 2171338
- J Cancer Prev.
- 2015 Jun;20(2):129-135.
- doi: 10.15430/JCP.2015.20.2.129
BACKGROUND: While the majority of angiogenesis studies have focused on the late stages of cancer, the emergence of neovascularization in colon tumorigenesis has been observed an earlier stage than expected.... -
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- Rapid visual detection of Mycobacterium avium subsp. paratuberculosis by recombinase polymerase amplification combined with a lateral flow dipstick
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Zhao G, Wang H, Hou P, He C, He H
- KMID: 2407623
- J Vet Sci.
- 2018 Mar;19(2):242-250.
- doi: 10.4142/jvs.2018.19.2.242
Paratuberculosis (Johne's disease) is a chronic debilitating disease of domestic and wild ruminants. However, widespread point-of-care testing is infrequent due to the lack of a robust method. The isothermal recombinase... -
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- Characterization of an Extracytoplasmic Chaperone Spy in Protecting Salmonella against Reactive Oxygen/Nitrogen Species
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Park YM, Lee HJ, Bang IS
- KMID: 2170789
- Int J Oral Biol.
- 2014 Dec;39(4):207-213.
- doi: 10.11620/IJOB.2014.39.4.207
Antimicrobial actions of reactive oxygen/nitrogen species (ROS/RNS) derived from products of NADPH oxidase and inducible nitric oxide (NO) synthase in host phagocytes inactivate various bacterial macromolecules. To cope with these... -
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- Development of a Mycobacterial Gene Knock-out System using Sequence-specific Recombinase FLP/FRT and its Application to the Construction of a Rhamnose Biosynthetic Gene rmlD Deletion Mutant
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Lee KC, Lee JS, Lee SJ, Lee KH, Lee TJ, Shin HJ, Choi JE, Park HS, Kim SK, Lee TY
- KMID: 1573280
- J Bacteriol Virol.
- 2002 Sep;32(3):221-230.
Development of a new and effecient tuberculosis vaccine is very important since the efficacy of the only available vaccine against tuberculosis, BCG, is variable among races and different ages. Attempts... -
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- AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus
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Koh W, Park YM, Lee SE, Lee CJ
- KMID: 2398423
- Exp Neurobiol.
- 2017 Dec;26(6):350-361.
- doi: 10.5607/en.2017.26.6.350
Adeno-associated virus (AAV)-mediated gene delivery has been proposed to be an essential tool of gene therapy for various brain diseases. Among several cell types in the brain, astrocyte has become... -
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- Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions
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Park YM, Chun H, Shin JI, Lee CJ
- KMID: 2430108
- Exp Neurobiol.
- 2018 Dec;27(6):508-525.
- doi: 10.5607/en.2018.27.6.508
Astrocyte is the most abundant cell type in the central nervous system and its importance has been increasingly recognized in the brain pathophysiology. To study in vivo function of astrocyte,... -
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