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Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon

Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR

  • KMID: 2433475
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):361-369.
  • doi: 10.5056/jnm14157
BACKGROUND/AIMS: Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine...
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New Generation Laxatives

Hong SN, Shin JE, Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Kim SE, Park KS, Choi SC, Constipation Research group of the Korean Society of Neurogastroenterology and Motility

A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride,...
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Strategy to Manage Irritable Bowel Syndrome in Korea

Kim JH, Sung IK

  • KMID: 2269332
  • Korean J Med.
  • 2014 Jun;86(6):695-697.
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between...
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Mechanism of Interdigestive Migrating Motor Complex

Takahashi

  • KMID: 2325917
  • J Neurogastroenterol Motil.
  • 2012 Jul;18(3):246-257.
Migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal contractions in the interdigestive state. This review article discussed the mechanism of gastrointestinal MMC. Luminal administration of 5-hydroxytryptamine...
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Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle

Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD

A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes....
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5-Hydroxytryptamine Generates Tonic Inward Currents on Pacemaker Activity of Interstitial Cells of Cajal from Mouse Small Intestine

Shahi PK, Choi S, Zuo DC, Yeum CH, Yoon PJ, Lee J, Kim YD, Park CG, Kim MY, Shin HR, Oh HJ, Jun JY

In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions...
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Treatment of Constipation

Park MI

  • KMID: 2258948
  • Korean J Med.
  • 2011 May;80(5):510-523.
Constipation is a common gastrointestinal disease affecting approximately 16.5% of the population in Korea. Systemic diseases such as hypothyroidism or colon cancer and drugs can cause constipation in some patients...
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Effects of Mosapride Citrate on the Motility of Stomach, Ileum and Colon in Conscious Guinea Pigs

Park CI, Jung IS, Lim JH, Kim NK, Kim H, Park H

  • KMID: 2307471
  • Korean J Neurogastroenterol Motil.
  • 2007 Jun;13(1):53-60.
BACKGROUND/AIMS: Mosapride citrate (Mosapride) is a relatively new selective 5-HT4 receptor agonist. Several studies have reported that mosapride selectively stimulates the upper GI motility, but not lower GI motility. However,...
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Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons

Chin C, Kim SI

  • KMID: 2166259
  • Genomics Inform.
  • 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin...
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Evaluation of the Role of 5-Hydroxytryptamine Receptor Subtypes in the Regulation of Nociceptive Transmission in the Rat Spinal Cord

Jeong CY, Bae HB, Park HC, Choi JI, Yoon MH

BACKGROUND: Spinal 5-hydroxytryptamine (5-HT) has been shown to display an antinociceptive effect, which is mediated by 5-HT receptors. Previous studies have revealed the presence of at least four types of...
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Effect of a Selective 5-HT4 Receptor Partial Agonist Tegaserod on Sensory Function and Compliance of Small Intestine in Humans

Jeong JJ, Choi MG, Cho YK, Jun EJ, Cho YS, Chung WC, Lee IS, Kim SW, Choi SW, Chung IS

  • KMID: 2255868
  • Korean J Neurogastroenterol Motil.
  • 2004 Jun;10(1):35-42.
BACKGROUND/AIMS: Disturbances in visceral perception contribute to postprandial symptoms in patients with functional dyspepsia. However, the mechanism of perceiving sensation has not been clearly defined. Our aim in this study...
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