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Expression of Neurokinin 1 Receptor in Allergic Rhinitis

Lee DJ, Lee HM, Lee SH, Hwang SJ

  • KMID: 1923200
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 Dec;44(12):1298-1302.
BACKGROUND AND OBJECTIVES: In airway tissues, the substance P has been suggested as the neurotransmitter in the afferent sensory nerve which responds to various irritants and that it may be...
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Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting

Lim CS, Ko YK, Kim YH, Park SI, Kim JK, Kim MJ, Kim HJ

BACKGROUND: 5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the...
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Electrophysiological study on the modulation of uterine mechanoreceptor by substance P

Na JY, Chang KH, Shin JC, You SW, Hong SC, Lee SE, Han HC

  • KMID: 2076230
  • Korean J Obstet Gynecol.
  • 2001 Apr;44(4):740-747.
OBJECTIVE: In inflammation, hyperalgesia is a common phenomenon but its mechanism has not been clarified. Recently some reports suggested substance P might be important factors for inflammatory hyperalgesia in somatic...
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita M, Fukuda T, Sato Y, Takasusuki T, Tanaka M

BACKGROUND: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the...
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The Effects of Substance P on the Proliferation Capability of Cultured Human Keratinocytes

Suh HS, Chang SE, Park EM, Choi JH, Sung KJ

  • KMID: 2303308
  • Korean J Dermatol.
  • 1998 Aug;36(4):595-601.
BACKGROUND: Recent evidence indicates that neurokinins released from cutaneous C-fibers can function as inflammatory mediators by activating cells of the immune system such as lymphocytes, monocytes and mast cells. Substance...
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Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients

Kim JJ, Kim N, Park JH, Kim YS, Lee SM, Lee DH, Jung HC

BACKGROUND/AIMS: Male predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism...
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Effect of Antidromic Impulses on the Mechanical Allodynia in a Rat Model of Peripheral Neuropathic Pain

Shin JW, Hahm KD, Leem JW, Park SH, Choi Y, Jung WS, Lee C

  • KMID: 1947093
  • J Korean Pain Soc.
  • 2003 Jun;16(1):14-22.
BACKGROUND: Nerve impulses that are transmitted, antidromically, into peripheral terminals, following nerve injury, may be a factor in neuropathic pain. The present study was designed to investigate the effects of...
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