- Sphingolipid Mediators of Myocardial Pathology
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Kovilakath A, Cowart LA
- KMID: 2470799
- J Lipid Atheroscler.
- 2020 Jan;9(1):23-49.
- doi: 10.12997/jla.2020.9.1.23
Cardiomyopathy is the leading cause of mortality worldwide. While the causes of cardiomyopathy continue to be elucidated, current evidence suggests that aberrant bioactive lipid signaling plays a crucial role as... -
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- Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
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Park SJ, Im DS
- KMID: 2367621
- Biomol Ther.
- 2017 Jan;25(1):80-90.
- doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G... -
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- Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells
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Im DS
- KMID: 2285242
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):139-142.
To examine intracellular signaling of human S1P3 (hS1P3), a sphingosine 1-phosphate (S1P) receptor in plasma membrane, hS1P3 DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of... -
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- Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis
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Park SJ, Im DS
- KMID: 2447859
- Biomol Ther.
- 2019 May;27(3):318-326.
- doi: 10.4062/biomolther.2018.131
Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of... -
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- Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients
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Choi HS, Kim KH, Jin S, Kim J, Yoo I, Pack SP, Ha UH, Park TW, Choi SA, Yuk SH, Kang SW, Jung YW
- KMID: 2424205
- Immune Netw.
- 2018 Oct;18(5):e39.
- doi: 10.4110/in.2018.18.e39
Sphingosine-1-phosphate (S1P) plays an important role in trafficking leukocytes and developing immune disorders including autoimmunity. In the synovium of rheumatoid arthritis (RA) patients, increased expression of S1P was reported, and... -
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- Bone marrow stem/progenitor cell mobilization in C57BL/6J and BALB/c mice
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Lee H, Che JH, Oh JE, Chung SS, Jung HS, Park KS
- KMID: 2312115
- Lab Anim Res.
- 2014 Mar;30(1):14-20.
- doi: 10.5625/lar.2014.30.1.14
Bone marrow (BM) has been considered as a reservoir of stem/progenitor cells which are able to differentiate into ectodermal, endodermal, and mesodermal origins in vitro as well as in vivo.... -
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- FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation
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Brinkmann
- KMID: 1726160
- Yonsei Med J.
- 2004 Dec;45(6):991-997.
- doi: 10.3349/ymj.2004.45.6.991
FTY720 is a novel immunomodulator that has proven effective in animal models of transplantation and autoimmunity, has achieved promising results in Phase I and Phase II studies of renal transplantation... -
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- Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins
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Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS
- KMID: 1094659
- Exp Mol Med.
- 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38... -
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